该【Pathobiology questions raised by telogen effluvium and trichodynia in COVID‐19 patients 2021 Anna Di Landro 】是由【四玉辈】上传分享，文档一共【2】页，该文档可以免费在线阅读，需要了解更多关于【Pathobiology questions raised by telogen effluvium and trichodynia in COVID‐19 patients 2021 Anna Di Landro 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。Received:21October2020 | Revised:4April2021 | Accepted:6April2021
DOI:
CORRESPONDENCE
Pathobiologyquestionsraisedbytelogeneffluviumand
trichodyniainCOVID-19patients
AlthoughcellreceptorsbindingCOVID-19appeartobelessex-cytokinessuchIL-6,TNFa,IL-1ß,IFNgallpromotecatagendevelop-
pressedintheskincomparedtootherorgans,1skinlesionsandhairmentinmurineand/
lossarecommonmanifestationsofthedisease(Supportinginforma-afterresolutionofthe“cytokinestorm.”
tionS1,S2).Trichodyniahasbeenassociatedwithtelogeneffluviumandmay
Werecentlyobserved39patientsinItalypresentingwithtelo-bedirectlyrelatedtotheseverityofhairsheddingandintensity
geneffluvium,(SupportinginformationS5).ThecombinationofTEwithtrichodynia
include9menand30womenageing48to73 years().raisesthequestionwhethertrichodyniamaybeaconsequenceofa
In16patients,COVID-19presentedwithsevereinterstitialpneu-similarneuropathologyastheoneleadingtoSARS-CoV-2-induced
monia,,wehaverecentlyshownthathuman
pressure(CPAP)(39)scalpHFscanindeed“smell,”thatisexpressfunctionalolfactory
systemicsteroids(25)anticoagulants(16).Symptomsdevelopedreceptors(namelyOR2AT4),whosecontinuousstimulationby,as
eightweekstothreemonthsafterclinicalmanifestationsCOVID-,unknownendogenousligandisrequiredforanagenmain-
Laboratoryexaminationsincludingthyroidfunction,iron,ferritintenanceviaintrafollicularinsulin-likegrowthfactor-
-19,whichcauses
thathairlossisanimportantclinicalcomplicationofSARS-CoV-2majorolfactorydamage,5alsoreducestheHFexpressionofhair
virusinfection,butalsoraisesintriguingquestionsastotheunderly-growth-promotingolfactoryreceptorssuchasOR2AT4causing
inghairfollicle(HF)-,angiotensin-convertingenzyme2
(ACE2)receptors,usedbythevirustoenterhumancells,arehighly
ageusiathathadgraduallyresolvedin4to5 weeks,waspresentinexpressedinkeratinocytesandsebaceousglands,althoughtheir
2/.
-Insummary,COVID-19isindeedassociatedwithTEandtricho-
patients,amarkedfeaturewasthepresenceofemptyfollicularostia
andtelogenclubhairsvisibleonthescalpsurface(Figure 1).Both
hairlossandtrichodyniaresolvedin2to4 months.
TEisthemostcommonformofdiffusehairsheddingduetothe
wasdescribedamongsymptomsofthedeadlyinfluenzapandemic
of1918–19(SupportinginformationS3),withhairlossreportedto
developafterameanof9
C()(SupportinginformationS4).Inourcases,thetimeframe
of2to3 monthsandapositivepulltestwithextractionoftelogen
-
cludedanageneffluviumastherewerenotbrokenhairsoryellow
-19infectionwasthemain
triggeroftheseverehairloss,otherfactorscouldhavecontributed
includinglessfrequentshampooing,worseningscalphealth,medi-
cationssuchasanticoagulantsandpoornutrition.
Pathobiologically,theCOVID-19-associatedsystemichyperin-FIGURE1 Dermoscopicimageshowingemptyfolliclesanda
2
flammatorysyndrome(“cytokinestorm”)isthemostlikelyexplana-telogenrootonthescalpsurface(50X)Absenceofbrokenhairs
tionofTEinthereportedcases,giventhatmostpro-inflammatoryexcludediffusealopeciaareata
©2021JohnWiley&SonsA/&SonsLtd
| ;00:1–2.
2 | CORRESPONDENCE
ACE2receptors,aswellasIL-6,inhumanHFbiologyandpathologyCorrespondence
todevelopnoveltherapeuticstrategiestailoredtotargetingtheseEllaGlaser,UniversityofMiamiMillerSchoolofMedicine
,1300
SouthMiamiAvenue,#2003,MiamiFL,33130,USA.
CONFLICTOFINTERESTEmail:******@
ADL,LNandEGdeclarethattheydonothaveanyconflictofinterest
-ORCID
sponsoredresearchontheOR2AT4ligand,Sandalore(seeCheretEllaGlaser -0001-7891-920X
).ATisaconsultantforDSLaboratories,MonatGlobal,
Almirall,TirthyMadison,EliLilly,LeoPharmaceuticals,BristolMyersREFERENCES
Squibb,P&,PincelliTPH,CriadoRFJ,AbdallaBMZ,BeldaJW.
PotentialinteractionsofSARS-CoV-2withhumancellreceptorsin
theskin:understandingtheenigmaforalowerfrequencyofskin
AUTHORCONTRIBUTION
.
ADL,LNandATdesignedtheresearchstudy,performedthere-,PeltanID,JensenP,-19-
search,:
;2(12):e754-e763.
,ItoN,SaathoffM,BettermannA,TakigawaM,Paus
-gammaisapotentinducerofcatagen-like
1
Anna .
1
Luigi Naldi2005;152(4):623-631.
Ella éretJ,BertoliniM,PonceL,
Ralf Paus2,3,;9:3624.
,LeoneF,LoffredoL,-19-RelatedAnosmia:the
Antonella Tosti2
.
2020;11:956.
1CentroStudiGISED,Bergamo,Italy
2DepartmentofDermatologyandCutaneousSurgery,University
ofMiamiMillerSchoolofMedicine,Miami,FL,USASUPPORTINGINFORMATION
3CentreforDermatologyResearch,NIHRManchesterAdditionalsupportinginformationmaybefoundonlineinthe
BiomedicalResearchCentre,UniversityofManchester,SupportingInformationsection.
Manchester,UK
4MonasteriumLaboratory,Münster,GermanyS1-S6:SupplementReferences.
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