该【Letter to the editor Serum anti-Aβ antibodies in cerebral amyloid angiopathy 2021 Yannick Chantran 】是由【周太监】上传分享，文档一共【4】页，该文档可以免费在线阅读，需要了解更多关于【Letter to the editor Serum anti-Aβ antibodies in cerebral amyloid angiopathy 2021 Yannick Chantran 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。AutoimmunityReviews20(2021)102870
ContentslistsavailableatScienceDirect
AutoimmunityReviews
journalhomepage:
Lettertotheeditor:Serumanti-Aβantibodiesincerebralamyloidangiopathy
ARTICLEINFO
Keywords
Anti-Aβantibodies
Naturalantibodies
Cerebralamyloidangiopathy
Stroke
Aβ-relatedangiitis
DearEditor,Aβ1–42(s-Aβ42)andAβ1–40(s-Aβ40)respectively,andallowedtobindin
◦
Sporadiccerebralamyloidangiopathy(CAA)relatestocerebrovas96-
◦
cularaccumulationofamyloidfibrilsmadeofamyloid-βpeptideAβ401:50to1:-HCl
[1].CAAisveryfrequentinAlzheimer'sdisease(AD)butalsoinnon--existingimmunecomplexes,then
,neutralizedinthesamevolumeof2xPBS4%,
◦
hemorrhagicfeatures(CAA-he)[2]and,inrarecases,withcortico
sensitiveAβ-relatedCNSvasculitis(CAA-relatedinflammation,CAA-ri)IgG,IgA,orIgMweredetectedusingappropriateantisera,andIgG
[3,4].
PathophysiologicalmechanismsleadingtoCAA-heandCAA-riarefromuncoatedwellsweresubtractedinordertoretainsignalsspecific
-AβantibodiesofIgGclasswereshowntoinforanti-,IgG2detectiondidnotyieldmeasurableresults.
creaseintheCSFduringCAA-ri[5,6],whichsuggestsanautoimmuneExperimentaldilutioncurveswerefittedtosigmoidmodels[16]that
,ADsubjectstreatedbyinfusionsofalloweddefining3parameters:
monoclonalanti-Aβantibodiesdevelopeddose-dependenthemorrhagicexcess,reflectingtheamountofantigenbindingsites,hencethedi
andvasculitisfeaturestermedamyloid-relatedimagingabnormalitiesversityofepitoperecognition;,correspondingtothedilution
(ARIAs)[7].Anti-Aβantibodiesbelongtothenaturalautoantibodyathalf-maximumsignal,dependingonconcentrationandavidityof
repertoire,asothernaturalauto-antibodiesinvolvedinneurodegenerpolyclonalantibodies;-maximum,
ativedisorders[8–11].GrossserumanalysesinADledtoinconsistentvaryingwithcooperativityphenomenabetweendistinctantibody
conclusions[12],whereasmorerefinedanalysessuchasanti-
subclasses,discriminatebetweenatypical(focal)andclassicalformsoflinearizationprocedure[17].Thesigmoidmodelingofexperimental
AD[13].Toourknowledge,thereisnopublisheddataregardingserumcurvesshowedexcellentgoodness-of-fit(meanR2=),andinternal
anti-Aβantibodiesinspontaneous(non-AD)CAA-riandCAA-%forallfour
Thiscase-controlprospectivestudyenrolled105participants:46parameters.
CAA-heinpatientsfulfillingthemodifiedBostoncriteriaforprobableorTable1presentstheanti-Aβserologicparametersindependently
definiteCAA[14];18CAA-riinpatientsfulfillingthecriteriafornon-associatedwithCAA,CAA-heandCAA-ri,ascomparedtocontrols,ac
invasivediagnosisofCAA-ri[15];
-,CAA-he-,and
-rimodelsconsideringindividualanti-Aβprofiles.
ForELISAanalysesofserumanti-Aβantibodiesdilutioncurves,driedAnalysesofbloodanti-Aβantibodiesdemonstratecomplexserolog
syntheticAβ1–40andAβ1–42aliquotsweredissolvedin10μLDMSO,icalprofilesinCAA,withdistinctivefeaturesinCAA-heandCAA-ri,and
sonicatedtoyieldmonomericforms,and,forfibrillarAβ1–42(f-Aβ42)andsuggeststheexistenceofdefinedcirculatinganti-Aβantibodyspecies
◦
Aβ1–40(f-Aβ40)respectively,-Aβantibody
dilutedto15μg/,160mMmanifestations,assuggestedinexperimentalmousemodels[18,19],and
2+
NaClforAβ1–40,or10mMNaClforAβ1–42,with10EqCuforsolubleinADpatientstreatedwithmonoclonalanti-Aβantibodies[7].This
/
Received18February2021;Accepted22February2021
Availableonline10June2021
1568-9972/©.
(2021)102870
Table1
MultivariablelogisticregressionmodelsforCAA,CAA-he,andCAA-riagainsthealthyagedcontrols.
VariablesEstimatesStandarderrorsZ---
CAAmodel
a
Anti-s-
Anti-s-
Anti-s-
a
Anti-f-
b
Anti-s-Aβ40IgMMaximum
c
Anti-s-Aβ42IgAAvidity
Anti-f-Aβ42IgG1Titer
VariablesEstimatesStandarderrorsZ---
CAA-hemodel
Anti-s-
Anti-f-Aβ42IgG4Titer
Anti-f-Aβ42IgG1Avidity
c
Anti-s-Aβ42IgAAvidity
b
Anti-s-Aβ40IgMMaximum
Anti-s-Aβ42IgG4Avidity
VariablesEstimatesStandarderrorsZ---
CAA-rimodel
a
Anti-s-
a
Anti-f-
Anti-s-Aβ40IgASteepness
Anti-s-Aβ42IgG4Steepness
b
Anti-s-Aβ40IgMMaximum
aVariablessharedbetweentheCAAandtheCAA-rimodels.
bVariablessharedbetweentheCAA,theCAA-heandtheCAA-rimodels.
cVariablessharedbetweentheCAAandtheCAA-hemodels.
dWald'stestp-valuescorrectedbytheBenjamini&Hochbergprocedure.
eUncorrectedLikelihoodRatiotestp-valuesagainstthe(k-1)model.
2
(2021)102870
processesinducedbyAβpathologicalspecies,,thelink
betweenself-replicatingproteins,inflammationandactiveauto-
immuneprocesseshasbeenunderlined[20,21].
Inconclusion,thiscorrelativestudydemonstratesdistinctserum
anti-AβantibodypatternsinCAAandresultinghemorrhagicandin
shouldelucidatethetriggeringroleofanti-Aβantibodiesinspontaneous
orimmunotherapy-inducedCAAmanifestations,andprovideappro
priatebiomarkersoftheseconditions.
Funding
ThisworkwassupportedbytheSATTLutech,Paris,France.
References
[1]CharidimouA,BoulouisG,GurolME,AyataC,BacskaiBJ,FroschMP,etal.
;140:
1829–50.
[2]B´ejotY,CordonnierC,DurierJ,Aboa-EbouleC,RouaudO,
haemorrhageprofilesarechanging:resultsfromtheDijonpopulation-basedstudy.
Brain2013;136:658–64.
[3]SalvaraniC,HunderGG,MorrisJM,BrownJrRD,ChristiansonT,-
relatedangiitis:comparisonwithCAAwithoutinflammationandprimaryCNS
;81:1596–603.
[4]SalvaraniC,BrownJrRD,ChristiansonTJH,Huston3rdJ,GianniniC,HunderGG.
Long-termremission,relapsesandmaintenancetherapyinadultprimarycentral
nervoussystemvasculitis:asingle-center35-
2020Apr;19(4):102497.
[5]PiazzaF,GreenbergSM,SavoiardoM,GardinettiM,ChiappariniL,RaicherI,etal.
Anti-amyloidβautoantibodiesincerebralamyloidangiopathy-relatedinflamma
tion:implicationsforamyloid-;73:449–58.
[6]DiFrancescoJC,LongoniM,-Aβautoantibodiesinamyloidrelated
imagingabnormalities(ARIA):candidatebiomarkerforimmunotherapyinAlz
heimer’;6:207.
[7]SperlingRA,JackJrCR,BlackSE,FroschMP,GreenbergSM,HymanBT,etal.
Amyloid-relatedimagingabnormalitiesinamyloid-modifyingtherapeutictrials:
recommendationsfromtheAlzheimer’sAssociationresearchroundtablework
;7:367–85.
[8]NeffF,WeiX,Nolker¨C,BacherM,DuY,
Jun;7(6):501–7.
[9]KrestovaM,HromadkovaL,
;2017:33–44.
[10]FolkeJ,RydbirkR,LøkkegaardA,-α-Synuclein
antibodypatternsinmultiplesystematrophyandParkinson’
Immunol2019;10:2253.
,[11]SzaboP,RelkinN,.
AutoimmunRev2008Jun;7(6):415–20.
CAA-modelpredictedvalueusingthelogisticmultivariableregressionmodel
[12]ChantranY,CapronJ,AlamowitchS,-Aβantibodiesandce
presentedinTable1,,CAA-;10:1534.
logisticmultivariableregressionmodelpresentedinTable1,,[13]Doroth´eeG,BottlaenderM,MoukariE,deSouzaLC,MaroyR,CorlierF,etal.
CAA-rimodelpredictedvaluesusingthelogisticmultivariableregressionmodelDistinctpatternsofantiamyloid-βantibodiesintypicalandatypicalAlzheimer
presentedinTable1,lowerpart.*:p<;**:p<;***:p<;69:1181–5.
[14]LinnJ,HalpinA,DemaerelP,RuhlandJ,GieseAD,DichgansM,
Wilcoxon'stest.
2010;74:1346–50.
studydrivesattentiontowardpotentiallyrelevantanti-Aβantibody[15]AurielE,CharidimouA,GurolME,NiJ,VanEttenES,Martinez-RamirezS,etal.
ValidationofClinicoradiologicalcriteriaforthediagnosisofcerebralamyloid
,multivariablestaAngiopathy-;73:197–202.
tisticalanalysispinpointstherelevanceofbothAβ1–40-andAβ1–42-[16]CheungYB,XuY,RemarqueEJ,
–
–40,;417:11523.
[17]OroszF,Ovadi´
maincomponentofCAAvasculardeposits,ourresultssuggestprefer;270:155–62.
[18]PfeiferM,BoncristianoS,BondolfiL,StalderA,DellerT,StaufenbielM,etal.
diversityofanti-solubleAβ1–40IgMwasalsoacommoncharacteristicofCerebralhemorrhageafterpassiveanti-;298:
bothCAA-heandCAA-riprofiles,whichcouldindicateadrivenIgM1379.
[19]ThakkerDR,WeatherspoonMR,HarrisonJ,KeeneTE,LaneDS,KaemmererWF,
responsetowardsomeparticularpathogenicAβ1–-betaantibodiesreducecerebralamyloid
-
–
ThecausalrelevanceofserologicaldifferencesinspontaneousCAAAcadSciUSA2009;106:45016.
[20]ButnaruD,-replicatingproteinsoninflammation,
-
theyrelatetopeculiarnaturalantibodyrepertoiresthatmightfavorCAAMar;18(3):231–40.
anditscomplicationsoriftheyratheremergefromB-cellselection[21]BonamSR,’sdiseaseisanautoimmunedisease:areappraisal.
AutoimmunRev2020Dec;19(12):102684.
3
(2021)102870
YannickChantrana,b,JeanCaprona,c,DianaDoukhia,JohannaFelixa,gServicedeNeurologie,CentreHospitalierdeSaint-Denis,Saint-Denis,
M´elanieFeroul´a,FlorianKrusea,ThomasChaigneaua,France
GuillaumeDoroth´eea,ThibaultAlloud,XavierAyrignace,ZinaBarrouf,hServicedeNeurologie,CentreHospitalierdeMeaux,Meaux,France
ThomasdeBrouckerg,CorinaCreth,GuillaumeTurci,RoxanePeresj,iServicedeNeurologie,GHUParis
Letter to the editor Serum anti-Aβ antibodies in cerebral amyloid angiopathy 2021 Yannick Chantran 来自淘豆网www.taodocs.com转载请标明出处.