An overview on the potential of natural products as ureases inhibitors A review.pdf.pdf

Journal of Advanced Research (2015) 6, 35–44
Cairo University
Journal of Advanced Research
REVIEW
An overview on the potential of natural products as
ureases inhibitors: A reviewq
Luzia V. Modolo a,*, Aline X. de Souza a,Lı´via P. Horta a,De´bora P. Araujo a,b,
Aˆngelo de Fa´tima b,*
a Departamento de Botaˆnica, Instituto de Cieˆncias Biolo´gicas, Universidade Federal de Minas Gerais, Av. Pres. Antoˆnio Carlos,
6627, Pampulha, Belo Horizonte, MG 31270-901, Brazil
b Departamento de Quı´mica, Instituto de Cieˆncias Exatas, Universidade Federal de Minas Gerais, Av. Pres. Antoˆnio Carlos,
6627, Pampulha, Belo Horizonte, MG 31270-901, Brazil
ARTICLE INFO ABSTRACT
Article history: Ureases, enzymes that catalyze urea hydrolysis, have received considerable attention for their
Received 14 July 2014 impact on anisms’ health and life quality. On the one hand, the persistence of urease
Received in revised form 21 activity in human and animal cells can be the cause of some diseases and pathogen infections.
September 2014 On the other hand, food production can be negatively affected by ureases of soil microbiota
Accepted 22 September 2014 that, in turn, lead to losses of nitrogenous nutrients in fields supplemented with urea as fertilizer.
Available online 13 October 2014 In this context, nature has proven to be a rich resource of natural products bearing a variety of
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