大气可吸入颗粒物造成肺损伤的NF-κB 研究进展.pdf

第21卷第2期生命科学 Vol. 21, No. 2
2009年4月 Chinese Bulletin of Life Sciences Apr., 2009
文章编号: 1004-0374(2009)02-0259-05
大气可吸入颗粒物造成肺损伤的 NF-κB 研究进展
彭辉,周绮云,刘璇,赵晓红*
(北京联合大学应用文理学院,北京 100083)
摘要:NF-κB 信号通路在大气可吸入颗粒物(PM10)对肺的损伤过程中起到重要的作用,但 NF-κB信号通
路参与的损伤机理尚不清楚。本文对 NF-κB 的结构与组成、颗粒物中 NF-κB 的激活因素、激活过程和抑
制剂的相关研究等内容做简要综述。
关键词:大气可吸入颗粒物;NF-κB 信号通路;NF-κB 通路抑制剂
中图分类号:X513; 文献标识码:A
Progress of study on the NF-κB signaling pathway in
the lung injury induced by inhalable particle
PENG Hui, ZHOU Qi-yun, LIU Xuan, ZHAO Xiao-hong*
(College of Applied Arts and Sciences, Beijing Union University, Beijing100083, China)
Abstract: Many epidemiologic studies have shown that the NF-κB signaling pathway plays an important role in
the lung injury by induction of inhaled particle matter. However, the exact toxicological damage mechanisms
which the NF-κB signaling pathway takes part in are still unresolved. This paper described the progress of study
on the NF-κB signaling pathway in the lung injury induced by inhaled particle matter home and abroad. In this
article, ponent of NF-κB, the activate factor of NF-κB in particle matter, the activation process and the
inhibitor were reviewed.
Key words: inhalable particle; NF-κB signaling pathway; NF-κB signaling pathway inhibitor
近年来,越来越多的流行病学、毒理学研究来越多的科学家致力于大气颗粒物对机体的毒性损
资料表明,大气可吸入颗粒物(inhalable particle, IP, 伤机制的研究。姜薇和赵晓红[6]