环氧化酶-2 和血管内皮生长因子在喉癌中的表达及临床意义.pdf

环氧化酶-2和血管内皮生长因子在喉癌中的表达及临床意义
陈祖尧1,余玲2,粱灼萍1,刘文军1,黎万荣1,覃纲1
(泸州医学院附属医院 1 耳鼻咽喉头颈外科;2 眼科,四川泸州 646000)
[摘要] 目的研究环氧化酶-2(Cyclooxygenase-2, Vascular endothelial growth factor(VEGF)in
COX-2)和血管内皮生长因子(vascular endothelial laryngeal carcinoma tissue and its clinical significance.
growth factor,VEGF)在喉癌中的表达及临床意义。 METHODS Sixty-five samples of laryngeal carcinoma
方法采用免疫组化SP法检测65例喉癌组织及34例癌 and thirty-four biopsies of adjacent noncancerous
旁组织中COX-2和VEGF表达,并结合相关临床病理参 tissue were immunohistochemically examined for
数进行分析。结果 COX-2和VEGF在喉癌中阳性表达 expression of COX-2 and VEGF, whose relationship
%%,均高于癌旁组织中的表达 with clinicopathological parameters was also analysied.
(P<),且两者表达呈显著相关性(P<)。 RESULTS Percentages of COX-2 and VEGF
COX-2表达与T分期和临床分期相关,VEGF表达则与 expression in laryngeal carcinoma tissue were %
临床分期和淋巴结转移相关(P<)。生存分析显 and % respectively, which were higher than those
示COX-2和VEGF阳性表达和阴性表达患者无瘤生存 in adjacent noncancerous tissue(P <). The
率和总生存率差异均有统计学意义(P<)。结论 expression of COX-2 in laryngeal carcinoma tissue was
COX-2和VEGF在喉癌组织表达异常增高,其在喉癌发 found to be associated with the expression of VEGF
生发展中可能发挥重要作用,且两指标的表达与喉癌不(P <).The expression of COX-2 significantly
良预后有关。 redated between patients with different T stage and
[关键词] 环氧化酶2;血管内皮生长因子类;喉肿瘤; clinical stage, and the expression of VEGF significantly
癌,鳞状细