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该【内科学教学课件：Peptic Ulcer Disease(PUD) 】是由【窝窝爱蛋蛋】上传分享，文档一共【94】页，该文档可以免费在线阅读，需要了解更多关于【内科学教学课件：Peptic Ulcer Disease(PUD) 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。PepticUlcerDisease(PUD)
Definition:
Defectsinthegastrointestinalmucosaextendingthroughthemuscularismucosaeintothesubmucosaormuscularis
Whycalledpepticulcers:
Persistandaregenerallydependentontheacid-pepticactivityofgastricjuice.
Introduction
HistologyofStomach
muscularis
mucosae
serosa
muscularis
submucosa
mucosa
Typicalchroniculcers:
Gastriculcer(GU)
Duodenalulcer(DU)
Atypicalulcers:
Atypicallocation
Anatomy
Twomajorcauses:
InfectionwithHp(helicobacterpylori)
ConsumptionofNSAIDs(nonsteroidalanti-inflammatorydrugs)
Mainmechanism:
Imbalancebetweenaggressiveacid-pepticactionandmucosaldefenses
EpidemiologyofPUD
Prevalencedefinition:
Theproportionofthepopulationwithagivendiseaseatasinglepointtime,overaperiodoftime,oroveralifetime.
PrevalenceofPUD:
MustbedefinedasafunctionofHpstatusandofNSAIDsuse
Howistheprevalence:
Estimatedfromendoscopicstudiesofadultvolunteers
About10%inpopulationoveralifetime
1-6%inHp+patientsbyatleastonescreeningtest
Alifetimeriskof10-20%inpatientswithHpinfection
PrevalenceofNon-HpandNon-NSAIDsisunknownbutisprobablyverylow.
EtiologyofPUD
MaincausesofPUD
Hpinfection
NSAIDsuse
Non-Hp,Non-NSAIDs
Detailsofetiologyanddiseaseassociations
Ulcersduetodefinedmechanisms
Definition:
Defectsinthegastrointestinalmucosaextendingthroughthemuscularismucosaeintothesubmucosaormuscularis
Whycalledpepticulcers:
Persistandaregenerallydependentontheacid-pepticactivityofgastricjuice.
Introduction
HistologyofStomach
muscularis
mucosae
serosa
muscularis
submucosa
mucosa
Typicalchroniculcers:
Gastriculcer(GU)
Duodenalulcer(DU)
Atypicalulcers:
Atypicallocation
Anatomy
Twomajorcauses:
InfectionwithHp(helicobacterpylori)
ConsumptionofNSAIDs(nonsteroidalanti-inflammatorydrugs)
Mainmechanism:
Imbalancebetweenaggressiveacid-pepticactionandmucosaldefenses
EpidemiologyofPUD
Prevalencedefinition:
Theproportionofthepopulationwithagivendiseaseatasinglepointtime,overaperiodoftime,oroveralifetime.
PrevalenceofPUD:
MustbedefinedasafunctionofHpstatusandofNSAIDsuse
Howistheprevalence:
Estimatedfromendoscopicstudiesofadultvolunteers
About10%inpopulationoveralifetime
1-6%inHp+patientsbyatleastonescreeningtest
Alifetimeriskof10-20%inpatientswithHpinfection
PrevalenceofNon-HpandNon-NSAIDsisunknownbutisprobablyverylow.
EtiologyofPUD
MaincausesofPUD
Hpinfection
NSAIDsuse
Non-Hp,Non-NSAIDs
Detailsofetiologyanddiseaseassociations
Ulcersduetodefinedmechanisms
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