甲亢平消汤联合小剂量他巴唑治疗GRAVES病的临床观察与研究.doc

甲亢平消汤联合小剂量他巴唑治疗GRAVES病的临床观察与研究
陈荣吴伟
(陕西中医学院第一附属医院,陕西咸阳 712000)
摘要:【目的】通过临床病例的对照分析,总结甲亢平消汤治疗GRAVES病的临床疗效并探讨其作用机制,进一步证实甲亢平消汤在GD治疗过程中的有效性、实用性。【方法】将80例GRAVES病患者随机分为两组,治疗组40例,对照组40例,分别给予中西药(甲亢平消汤联合小剂量他巴唑片)及单纯西药(常规剂量他巴唑片)进行治疗,观察患者在服药后3个月内各观测时间点的主要症状及体征改善情况、实验室指标变化。【结果】该临床观察治疗后疾病疗效判定比较:治疗组:%;对照组:总有效率 %。两组比较有显著性差异(P<),中西药组在治疗GRAVES病的临床总疗效方面优于单纯西药组。【结论】甲亢平消汤联合小剂量他巴唑治疗GD病临床疗效确实可靠,在提高疗效、缩短病程、迅速缓解甲状腺毒症、减少西药用量及不良反应发生事件、防止和减低复发等方面具有突出优势,值得临床进一步推广应用。
关键词:甲亢平消汤;他巴唑;GRAVES病;临床疗效观察
Clinical Research Of Remedying Graves Disease With Jiakangpingxiao
bined With Small Dose of MMI
ABSTRACT:【Objective】to summary clinical effect of jiakangpingxiao decoction and to explore its’ mechanism through parative analysis of
clinical cases.【Method】Randomly divided into two groups: the treatment group, 40 patients ,is given jiakangpingxiao bined with low dose levels of MMI tablets; the control group, 40 patients,were only given conventional dose of MMI tablets, to observe these patients taking the drug within 3 months after the observation time point of the main symptoms and signs of improvement.【Resu1t】jiakangpingxiao decoction in the treatment of GD patients in terms of overall clinical efficacy than the control group. 【Conclusion】jiakangpingxiao bined with low dose MMI has indeed reliable clinical effect in improving the efficacy,
1
shorten the course, quickly alleviate the thyrotoxicosis , dosage and adverse reactions medicine to reduce incidents and prevent and reduce relapse, and so has outstanding advantages,worthy of further clinical application.
Key Words: jiakangpingxiao decoction; MMI; Graves disease; Clinical effect observation
Graves病(简称GD),即毒性弥漫性甲状腺肿,是一种伴T3、T4分泌增多的
器官特异性自身免疫病,占全部甲亢患者的85﹪左右。普通人群中本病的患病率为1%,发病率15/10万~50/10万,女性显著高发(4-6):1,高发年龄为20~
【1】50岁。近年来,随着人们生活压力的增加和工作节奏的加快,
本病的发病率有明显增高的趋势。由于本病的病因与发病机制还未完全阐明,所以完全针对病因的治疗措施尚无从谈起。而且,此病一旦罹患,持续多年,并经常反复,严重影响患者日常生活、工作和学****因此,关于本病的研究和防治工作也就显得格外重要和紧迫。自2009年7月至2010年1月,笔者用自拟甲亢平消汤联合小剂量他巴唑治疗GRAVES病40例,