Cytotoxicity and enhancement of the insulin signaling pathway induced by peroxidovanadium(V) complexes.pdf.pdf

anica Chimica Acta 420 (2014) 53–59
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anica Chimica Acta
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Cytotoxicity and enhancement of the insulin signaling pathway induced
by peroxidovanadium(V) complexes
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Seiichi Matsugo a,b, , Hironori Sugiyama c, Yuki Nishimoto d, Hirofumi Misu f, Toshinari Takamura f,
Shuichi Kaneko f, Yukari Kubo e, Reina Saito e, Kan Kanamori e
a Faculty of Natural System, Institute of Science and Engineering, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan
b CREST, Japan Science and Technology Agency (JST), Chiyoda-ku, Tokyo 102-0075, Japan
c Institute of Science and Engineering, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan
d School of Natural System, College of Science and Engineering, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan
e Department of Chemistry, Faculty of Science, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan
f Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, Japan
article info abstract
Article history: pounds are known to possess a variety of physiological actions, including insulin-mimetic
Available online 10 February 2014 activities. We synthesized two peroxidovanadium(V) complexes (pVs) having the amino acid der