Insulin resistance is not associated with thermogenic effect of a high-fat meal in obese children.pdf.pdf

NUTRITION RESEARCH 34 (2014) 486– 490
Available online at
ScienceDirect

Insulin resistance is not associated with
thermogenic effect of a high-fat meal in
obese children
Jeremy Chan a, Jefferson P. Lomenick b, Maciej S. Buchowski c, Ashley H. Shoemaker b,⁎
a School of Medicine, Vanderbilt University, Nashville, TN, USA
b Division of Pediatric Endocrinology, Vanderbilt University, Nashville, TN, USA
c Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
ARTICLE INFO ABSTRACT
Article history: In adults, insulin resistance may decrease the thermogenic effect of food, contributing to
Received 18 February 2014 weight gain. We aimed to determine the effect of insulin resistance on energy expenditure
Revised 2 June 2014 in children with long-standing obesity. We hypothesized that thermogenic effect of food
Accepted 4 June 2014 would decrease with increasing insulin resistance. Energy expenditure was measured using
whole room indirect calorimetry in obese children 7 to 18 years old. Participants were fed a
Keywords: high-fat meal with energy content equal to 35% of measured resting energy expenditure.
Obesity Thermogenic effect of food was measured for 180 minutes posttest meal and expressed as a
Insulin resistance percent of calories consumed. position was assessed using whole-body dual-
Energy metabolism energy x-ray absorptio