Isobavachalcone attenuates haride-induced ICAM-1 expression in brain endothelial cells through blockade of toll-like receptor 4 signaling pathways.pdf.pdf

European Journal of Pharmacology 754 (2015) 11–18
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European Journal of Pharmacology
journal homepage: ate/ejphar
Immunopharmacology and inflammation
Isobavachalcone attenuates haride-induced ICAM-1
expression in brain endothelial cells through blockade
of toll-like receptor 4 signaling pathways
Kwang Min Lee a, Jae Mi Kim a, Eun Joo Baik a, Jae Ha Ryu b, Soo Hwan Lee a,n
a Department of Physiology, School of Medicine, Ajou University, Suwon 443-749, Republic of Korea
b College of Pharmacy, Sookmyung Women's University, Seoul 140-742,Republic of Korea
article info abstract
Article history: Inflammation has been implicated in the pathogenesis of various cerebral diseases. Thus, control of brain
Received 2 October 2014 inflammation is regarded as one of the important therapeutic strategies for the treatment of
Received in revised form neurodegenerative diseases such as Alzheimer's disease and stroke. Isobavachalcone, a flavonoid from
10 February 2015 Psoralea corylifolia, is known to possess a wide spectrum of biological activities and is expected to be
Accepted 11 February 2015
useful in preventing or treating neurodegenerative diseases. However, very little is known regarding its
Available online 19 February 2015
effects on cerebral inflammation. In this study, we examined the effect of isobavachalcone on leukocyte
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