Modified sham feeding of foods with different positions differentially influences cephalic change of insulin, ghrelin, and NMR-based metabolomic profiles.pdf.pdf

Physiology & Behavior 135 (2014) 135–142
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Physiology & Behavior
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Modified sham feeding of foods with different macronutrient
compositions differentially influences cephalic change of insulin, ghrelin,
and NMR-based metabolomic profiles
Yong Zhu a,1,, James H. Hollis a,⁎
a Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States
b Department of Biomedical Sciences, Iowa State University, Ames, IA, United States
HIGHLIGHTS
• Modified sham feeding induced a macronutrient-specific cephalic change in insulin and ghrelin.
• Modified sham feeding resulted in a macronutrient-specific cephalic change in metabolomic profiles.
• Plasma glucose increased after modified sham feeding but this was not macronutrient-specific.
article info abstract
Article history: Little is known about the effect of the position of foods on cephalic phase response of
Received 7 April 2014 gastrointestinal hormones. In addition, the metabolomics of cephalic phase response has not been studied before.
Received in revised form 10 June 2014 The objective of the present study was to assess cephalic phase endocrinological and metabolomic responses
Accepted 11 June 2014
following modified sham feeding (MSF) of foods with different positions. Ten healthy
Available online 18 June 2014
males