Overexpression of sphingosine kinase 1 in liver reduces triglyceride content in mice fed a low but not high-fat diet.pdf.pdf

Biochimica et Biophysica Acta 1851 (2015) 210–219
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Biochimica et Biophysica Acta
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Overexpression of sphingosine kinase 1 in liver reduces triglyceride
content in mice fed a low but not high-fat diet
Greg M. Kowalski a,b,⁎, Joachim Kloehn c, Micah L. Burch b, Ahrathy Selathurai a, Steven Hamley a,
Stéphanie . Bayol a, Séverine Lamon a, Matthew J. Watt b,-Youngd,
Malcolm J. McConville c, Clinton R. Bruce a,b
a Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria 3125, Australia
b Biology of Lipid Metabolism Laboratory, Department of Physiology, Monash University, School of Biomedical Sciences, Clayton, Victoria 3800, Australia
c Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria 3010, Australia
d Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia
article info abstract
Article history: Hepatic insulin resistance is a major risk factor for the development of type 2 diabetes and is associated with the
Received 23 September 2014 accumulation of lipids, including diacylglycerol (DAG), triacylglycerols (TAG) and ceramide. There is evidence