malignant solitary fibrous tumor in retroperitoneum 2017 yihong zhou资料.pdf

该【malignant solitary fibrous tumor in retroperitoneum 2017 yihong zhou资料 】是由【四婆子】上传分享，文档一共【4】页，该文档可以免费在线阅读，需要了解更多关于【malignant solitary fibrous tumor in retroperitoneum 2017 yihong zhou资料 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。?ClinicalCaseReportMedicineOPENMalignantsolitary?broustumorinretroperitoneumAcasereportandliteraturereview?YihongZhou,MD,XiChu,MD,YeYi,MD,LiangTong,MD,YingboDai,MDAbstractRationale:Solitary?broustumor(SFT):WereportacaseofmalignantretroperitonealSFTina59-year-oldmanpresentedwithright?,es:Alaparotomyandresectionofthetumorwereperformed,thehistopathologicandimmunohistochemical?,andthepatienthadnosignsofrecurrenceormetastasisatthe12monthsfollow--:putedtomography,SE=surgicalexcision,SFT=solitary?:literaturereview,malignanttumor,retroperitoneum,solitary??broustumor(SFT)ursA59-year-oldmanpresentedwithright?,andaboutThepatientdeniedanyothersymptoms,aswellasrecentweight30%to40%ofSFTsariseinextra-pleuralregions.[1]-RetroperitonealSFTsareasubgroupofextra-pleuralSFTs,tionshowednoabnormal?ndings,exceptforanonpainfulmassoftenpresentwithnonspeci?(CT)scanshowedawell-?13?10cmMalignantSFTinretroperitoneumisextremelyrare,pressingtherightkidneyevidenceofonly9casesofmalignantretroperitonealSFTs().Basedonthese?ndings,aretroperitonealtumor–publishedinliterature.[27]Inthepresentstudy,,asmooth-,:,-ThisworkwassupportedbytheNationalNaturalScienceFoundationofChinalularregions().Thetumorconsistedofamixtureofbland(grantnumber81470925)(grantnumber2016zzts156).addition,moderateatypicalmitoses(4mitosesper10highpowerTheauthorshavenocon?ictsofinteresttodisclose.?led[HPF])werefound().DepartmentofUrology,TheThirdXiangyaHospitalofCentralSouthUniversity,Onimmunohistochemicalstudies,theantibodiesemployedareChangsha,Hunan,,?Correspondence:YingboDai,DepartmentofUrology,TheThirdXiangyareactivityisregardedasthemostprominentcharacteristic?ndingHospitalofCentralSouthUniversity,138TongzipoRoad,Changsha,HunaninthediagnosisofSFT.[8,9]Otherpositiveimmunoreactivitiesin410013,China(e-mail:daiyingbo0622@).,thetumorCopyright?2017theAuthor(s).PublishedbyWoltersKluwerHealth,(),CD99(),monsAttribution-,mercialvimentin(),andSTAT6()andnegativeforS100,mercial,aslongasitispassedalongunchangedandinwhole,withCD117,HMB45,EMA,SMA,andDog--67wasabout20%().BasedonthehistopathologicMedicine(2017)96:11(e6373)andimmunohistochemical?ndings,thediagnosisofamalignantReceived:8December2016/Receivedin?nalform:26January2017/:-http://dx./.Medicine(2017)96:11MedicineFigure1.(A)NoncontrastabdominalCTshowedawell-circumscribedmassinretroperitoneum.(B,C)ContrastabdominalCTshowedaslightlyenhancedmass,compressingtherightkidney.(B)Coronalsectionsand(C).(A)-shapedcellswithpatternlesspattern(magni?cation?200).(B)Nuclearmitoseswereseen(arrow)(magni?cation?400).(C)ImmunohistochemicalstainingforCD34waspositive(magni?cation?200).(D)ImmunohistochemicalstainingforCD99waspositive(magni?cation?200).(E)Immunohistochemicalstainingforvimentinwaspositive(magni?cation?200).(F)ImmunohistochemicalstainingforSTAT6waspositive(magni?cation?400).(G)TheKi-67indexwasabout20%.(2017)96:arehelpfulincon?,,isregardedasapositivemarker.[8,9]InAntibodySourceDilutionaddition,thepositive?ndingsforBcl-2,vimentin,andCD99CD34ZSGB-BIO,China1:,SFTgenerallyCD99ZSGB-BIO,China1:100showsnegativeexpressionofS100,cytokeratin,EMA,SMA,VimentinZSGB-BIO,China1:100CD117,CD31,,severalstudieshavefoundSTAT6Maximbiotech,China1:100thatNAB2-urredinthevastmajorityofS100ZSGB-BIO,China1:100SFTs.[15,16]InthestudybyUrabeetal,[17]theyfoundthatSTAT6CD147ZSGB-BIO,China1:,theroleofIHCHMB45Maximbiotech,China1:,inthepresentEMAMaximbiotech,China1:100SMAZSGB-BIO,China1:50study,theimmunohistochemicalstainingforSTAT6wasDog-1Maximbiotech,China1:,wefoundthatthetumorcellsstainedKi-67ZSGB-BIO,China1:?-67,aproliferation-associatedantigen,,andthephasesofthecellcycleincludingG1,S,G2,[18]performedimmunohistochemicalstainingforKi-67in24follow-(14patients)andmalignant(10patients)-%%formalignantSFTs(P<).-67couldbediagnosticallyrelevanttotheSFT,?rstreportedin1931byKlempererandRabin,[10],theKi-%,showingthetumorwascapableofhighdegreeofwidevarietyofextra-pleuralsitesalsohavebeennoted,,nasalcavity,salivaryglands,upperrespiratorytract,,peritoneum,retroperitoneumandpelvis,genitourinaryThe?ndings,suchasawell-circumscribedmass,T2hypointen-system,andsofttissue.[11,12]Itisreportedthat30%to40%icresonanceimaging,avidandheterogeneousSFTsarelocatedatextra-pleuralregions.[1]icresonanceimages,allindicateisrare,<100caseshavebeenreportedintheliterature.[13]thediagnosisofSFTs.[19]However,theimaging?ndingsofSFTsHistomorphologically,SFTtypicallyexhibitsapatternlessarevariableandnotspeci?,severalstudieshavepatterncharacterizedbyahaphazard,[5]spindlecellsandahemangiopericytoma-,,the10%to20%,riteriaforSimilarly,Urabeetal[17]reportedacaseofomentalSFTthatmalignancyareasfollows:highcellularity,highmitoticactivitypresentedasagastrointestinalstromaltumorofthesmall(morethan4mitosesper10HPF),pleomorphism,necrosis,,theCTscanrevealedthatthefeedinghanges.[14]Tothebestofourknowledge,only9arterytothetumormightbetheleftgastroepiploicartery,anditcasesofmalignantSFTinretroperitoneumhavebeenreportedinwas?nallyprovedthatthetumorwasoriginatedfromthegreatertheEnglish-languageliterature(summarizedinTable2).,detectingthefeedingarterymaybehelpfulforAsSFTisoriginatedfromspindlecellneoplasm,,Surgicalexcision(SE)isthebasictreatmentprincipleforbothin?ammatorymyo?broblastictumor,angiomyolipoma,,Rajeevetal[13],ImmunohistochemicalReference/eper10HPFpositiveVallat-Decouvelaere40M17SEYes,12moLung,12moAWD,(1998)[2],168moNoNED,180mo15UA70F10SENoNoNED,(2008)[3],CD99,Bcl-2UAMUASENoNoUA10CD34,CD99,Bcl-2Itoetal(2008)[4],30moUACD34,CD99,Bcl-2,vimentin,p53Baeetal(2011)[5]59M22SENoNoNED,36mo10CD34,CD99,Bcl-2Baldietal(2013)[6]41MUASEYes,23yUADOD,24yUAUAYohetal(2014)[7]43M17SE+ACNoNoNED,12mo3CD34,CD99,Bcl-2,vimentin,Ki-67(37%)Present59M14SENoNoNED,12mo4CD34,CD99,vimentin,STAT6,Ki-67(20%)AC=adjuvantchemotherapy,AWD=alivewithdisease,DOD=deadofdiseases,HPF=highpower?led,NED=noevidenceofdisease,SE=surgicalexcision,SFT=solitary?broustumor,UA=(2017)96:11MedicineDatabaseand24patientsfromsystematicreviewofpublished[6]BaldiGG,hiottiS,MauroV,?broustumorofallsites:;3:4.?[7]YohT,SataR,KobayashiA,?;99:414–[8]vandeRijnM,LombardCM,?broustumorsofthepleura,mediastinum,;18:814–20.[20,21][9]HanauCA,?broustumor:,;26:440–.[22,23]Thus,theuseofroutineadjuvant[10]KlempererP,:areportof?;11:385–412.?—,pletelyresectedand[11],;31:568–[12]HasegawaT,MatsunoY,ShimodaT,?brousrecurrenceormetastasisatthe12monthsfollow-:,wepresentararecaseofmalignantSFTinHumPathol1999;30:1464–-67label[13]RajeevR,PatelM,JayakrishnanTT,?broustumor:;plete5:[14]EnglandDM,HochholzerL,,theuseofroutineadjuvantradiationormalignant?-;13:640–58.?follow-upisnecessary.[15]RobinsonDR,WuYM,Kalyana-SundaramS,-STAT6genefusionsinsolitary?;45:180–[16]ChmieleckiJ,CragoAM,RosenbergM,-exomesequencingidenti?esarecurrentNAB2-STAT6fusioninsolitary?,MD,2013;45:131–.[17]UrabeM,YamagataY,AikouS,?broustumorofthegreateromentum,mimickinggastrointestinalstromaltumorofthesmallintestine:;100:836–