顺铂 IL-2胸腔内灌注治疗老年晚期肺腺癌恶性胸腔积液.doc

【摘要】目的:观察顺铂+il-2胸腔内灌注联合培美曲塞全身化疗治疗老年晚期肺腺癌恶性胸腔积液的临床疗效及毒副反应。方法:老年肺腺癌并胸腔积液患者共51例,采用顺铂40mg/m2及il-2150万u胸腔灌注保留,每周一次,共2周,同时应用培美曲塞,第1天,每3周重复,完成2个周期。治疗第4周评价疗效及毒副作用。结果:51例患者均可评价疗效,完全缓解者16例,部分缓解者25例,无效者6例,%,%。结论:顺铂+il-2胸腔内灌注联合培美曲塞全身化疗治疗老年晚期肺腺癌恶性胸腔积液治疗的方法疗效显著,毒性反应轻,临床使用安全。【关键词】顺铂;il-2;培美曲塞;老年;肺腺癌;胸腔积液clinicalobservationofcisplatin+il-hemotherapyforelderlypatientswithadvancedmalignantpleuraleffusionoflungcancer/wangyong-ming,jingli-jun,fenggui-xin,etal.//medicalinnovationofchina,2012,9(31):018-019【abstract】objective:observationoncisplatinandil-hemotherapyforelderlypatientswithadvancedmalignantpleuraleffusionoflungadenocarcinoma’:thelungadenocarcinomainelderlypatientswithpleuraleffusionatotalof51cases,theintrathoracicinjectionofcisplatin(40mg/m2)andil-2(),pemetrexeddisodiumforinjection(500mg/m2),thefirstday,every3weeksrepeated,:51patientscouldbeevaluatedtheeffects,pletelyalleviated,apartofthemitigationin25cases,%,%.conclusion:cisplatinandil-hemotherapyisaeffectivetreatmentmethodforelderlylungadenocarcinomapatientswithadvancedmalignantpleuraleffusionwhichwerelighttoxicityandsafeclinicaluse.【keywords】cisplatin;il-2;pemetrexeddisodium;elderly;lungadenocarc