全蛋及去蛋黄替代物摄入对代...鼠脂代谢调控作用的比较分析 于智慧.pdf

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现代食品科技L/6雄性小鼠分成空白对照组（Normal diet，ND）、模型组（High-fat diet，HFD）、全蛋摄入组（High-fat diet+egg，
EGG）、去蛋黄替代物组（High-fat diet+substitute of free egg yolk，SUB）和洛伐他汀组（Lovastatin，Lov）。实验周期为60 d，末期测
定脏器指数、相关生化指标、组织切片及相关酶水平。结果显示，EGG摄入显著抑制小鼠体重增长（p<）。EGG血清中低密度脂
蛋白胆固醇（low-density lipoprotein cholesterol，LDL-C）和总胆固醇（total cholesterol，TC）%%。
较HFD组，EGG和SUB抑制了由HFD引起的肝脏中超氧化物歧化酶（superoxide dismutase，SOD）和丙二醛（malondialdehyde，MDA）
含量上升，%%，同时SUB组肝脏中TC和甘油三酯（serum triglyceride，
TG）最低， mmol/ mmol/L。EGG显著降低肝脏天冬氨酸转氨酶（aspartate transaminase，AST）和天冬氨酸转氨酶
/丙氨酸转氨酶（AST/ALT）比值（p<），%%。此外，EGG能显著抑制肝脏脂滴的形成和附睾脂肪细
胞增大（p<）。因此，较SUB，EGG能更好地调控MetS小鼠的血脂代谢。
关键词：全蛋；去蛋黄替代物；代谢综合征；小鼠；脂代谢
DOI: .1673-
Comparative Analysis of Effects of Whole Egg and Substitute of Egg Yolk
Consumption on Lipid Metabolism in Mice with Metabolic Syndrome
YU Zhihui, ZHOU Liyuan, ZHU Yingchun*
(Food Science School of Engineering, Shanxi Agricultural University, Taigu 030801, China)
Abstract: In order to study the effects of whole egg and substitute of egg yolk consumption on lipid metabolism in mice with metabolic
syndrome (MetS), a MetS mouse model was constructed through high-fat feeding in this experiment. Forty C57BL/6 male mice were divided
into control group (normal diet, ND), model group (high-fat diet, HFD), whole egg consumption group (high-fat diet+egg, EGG), substitute of
egg yolk consumption group (high-fat diet+substitute of free egg yolk, SUB) and lovastatin group (Lov). The organ index, biochem