SPECIAL ISSUE on the Most Powerful Idea in Science Evolution at Work How Doctors, Police and Others Use It on the Job January 2009 $ . . £ The Evolution of EVOLUTION How Darwin’s Theory Survives, Thrives and Reshapes the World The Future of Human Evolution Molecular Proof of Natural Selection How Life Invents Complex Traits Creationists’ Latest Tricks features ■ Scientific American January 2009 ■ Volume 300 Number 1 SPECIAL ISSUE 24 the evolution of Evolution INTRODUCTION 24 Darwin’s Living Legacy By Gary Stix This Victorian scientist constructed his revolutionary theory of evolution through natural selection over a lifetime of meticulous observation and thought. As perhaps the most powerful idea in science, it still drives the contemporary research agenda. Kenn Brown, Mondolithic Studios MODES OF SELECTION 30 Testing Natural Selection 30 By H. Allen Orr Biologists working with the most sophisticated ic tools are demonstrating that natural selection plays a far greater role in shaping DNA than even most evolutionists had thought. SOURCES OF VARIATION 38 38 From Atoms to Traits By David M. Kingsley Random variations anisms provide fodder for evolution. Modern scientists are revealing how that diversity arises and how even simple DNA changes 50 can add up plex creatures and cultures. FAMILY TREE 46 The Human Pedigree By Kate Wong Some 180 years after unearthing the first human 46 fossil, paleontologists have amassed a formidable record of our forebears. On The Cover ANATOMY From finch beaks to genes to the future of This Old Body humanity, Charles Darwin’s profound insights 50 about evolution have shaped our view of life. By Neil H. Shubin Cover concept by Jen Christiansen. Evolutionary hand-me-downs inherited from fish cover images: TIME LIFE PICTURES/Getty Images (Charles Darwin); KENN BROWN Mondolithic and tadpoles have lef