141例慢性乙型肝炎肝组织病理与临床相关性分析.doc

141例慢性乙型肝炎肝组织病理与临床相关性分析
【摘要】目的:例慢性乙型肝炎患者进行肝脏活检穿刺,并做相关病理HE染色,特殊染色、对其血清学指标、实时组织弹性成像(RTE)指标和临床有关资料进行研究分析。结果:(1)不同ALT组与肝脏炎症分级、纤维化分期比较,P值均< ,差异均有统计学意义,可认为随着 ALT 的逐渐升高,肝脏炎症分级和纤维化分期也随之升高;(2)不同GLB组与肝脏炎症分级、纤维化分期比较,P值均< ,差异均有统计学意义,可认为随着GLB的逐渐升高,肝脏炎症分级和纤维化分期也随之升高;(3)不同HBV DNA定量组与肝脏炎症分级,纤维化分期比较,P值均?,差异没有统计学意义,可认为HBVDNA水平与肝脏病理炎症分级和纤维化分期均没有关系;(4)不同纤维化组与实时组织弹性成像结果比?^,P值<,差异有统计学意义,可认为kappa值随着纤维化程度加重而逐步升高。结论:慢性乙型肝炎的炎症分级和纤维化分期在临床诊断和病理诊断中存在一定差异,提示对无禁忌症患者进行肝穿活检有助于肝脏疾病的诊断治疗和预后评估。
【关键词】慢性乙型肝炎;实时组织弹性成像;肝脏炎症分级;肝脏纤维化分期
[Abstract] Objective:To analyze the correlation between the clinical results and the pathological results of chronic hepatitis :The liver biopsy was performed on 141 patients who have diagnosed as chronic hepatitis B. The results of the hematoxylin-eosin staining(HE) , the specific staining, the blood tests, the real-time tissue elastography (RTE) and the clinical results were :(1) The liver inflammation grading and fibrosis stage increased as the level of ALT rose (P ), (4) There was significant significant difference (P< ) between different fibrosis group on RTE, the KAPPA value increased with the aggravation of liver :There were some differences on the liver inflammation grading and fibrosis stage between the clinical results and the pathological results of chronic hepatitis B. The liver biopsy may be helpfu