胼胝体切断对健侧C7移位术后跨大脑两半球功能重组.doc

胼胝体切断对健侧C7移位术后跨大脑两半球功能重组.doc胼胝体切断对健侧C7移位术后跨大脑两半球功能重组
【摘要】明确胼胝体在健侧C7移位术后跨大脑两半球功能重组过程中所起的作用。[方法] 将45只SD大鼠随机分为正常对照组、健侧C7移位模型术后和胼胝体切断术后3个月、5个月、7个月、10个月共9组。采用运动皮层内微电极电刺激技术,定量评价大鼠患肢正中神经代表区在双侧初级运动皮层(MI)内的可塑性变化。[结果]健侧C7移位正中神经术后3个月,患肢正中神经代表区在双侧MI均未出现,术后5个月则仅出现于患肢同侧MI,术后7个月在双侧MI均出现,术后10个月则只出现于对侧MI。而胼胝体切断术后5、7和10个月,患肢正中神经代表区均只出现于患肢同侧MI。[结论]在健侧C7移位大鼠模型上证实术后10个月内运动皮层出现了跨大脑两半球的功能重组,胼胝体在该重组中起关键的通道作用。
【关键词】臂丛脊神经根神经损伤神经移功能重组
Abstract [Objective]To explore the role of callus during transhemispheric anization progress after contralateral seventh cervical nerve root transfer to the affected median nerve[Method] Forty-five adult male Sprague-Daodels odel of contralateral C7 cervical nerve root to median nerve, as y model Each model included 4 groups according different intervals of examination Intracortical microstimulation edian nerve representation region in bilateral primary motor cortex (MI) at different intervals, namely 3, 5, 7 and 10 months postoperatively[Result] After stimulating bilateral MI, median nerve representation region of the affected forelimb appeared only in the ipsilateral MI instead of contralateral MI at 5 months after the nerve transfer At 7 months it appeared in MI of both hemispheres Yet at 10 months it appeared merely in the contralateral MI Hoedian nerve representation region of affected forelimb appeared merely in the ipsilateral MI at 5, 7 and 10 months after callosotomy[Conclusion] T