替米沙坦防治糖尿病大鼠血管内皮损伤的实验研究.pdf

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·38· 中国循证心血管医学杂志 2011 年 3 月第 3 卷第 1 期 Chin J Evid Based Cardiovasc Med March 2011 Vol. 3 No. 1
论著
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替米沙坦防治糖尿病大鼠血管内皮损伤的实验研究
吴仕平,陈明
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[摘要] 目的观察替米沙坦对糖尿病大鼠血管内皮细胞形态、功能的影响探讨其对糖尿病血管内皮
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损伤的防治作用。方法建立糖尿病大鼠模型大鼠分组并给予不同干预观察血管内皮细胞的形态、功能各
组间进行比较与正常组比较,透射电镜下糖尿病组大鼠血管内皮细胞发生肿胀坏死脱落等改变,
。结果①、、
血清一氧化氮水平明显低于正常组与糖尿病组比较,透射电镜下替米沙坦组大鼠血管内皮细胞
P < 0. 05 ②
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形态明显改善血清一氧化氮水平明显升高 P < 0. 05 。结论糖尿病大鼠血管内皮细胞形态、功能异常发
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生了损伤性变化替米沙坦能明显改善糖尿病大鼠血管内皮细胞的形态和功能。
[关键词] 糖尿病替米沙坦内皮细胞内皮损伤
[中图分类号]R587. 1 [文献识别码]A [文章编号]1674-4055 2011 01-0038-03
Prevention and treatment of vascular endothelium impairment with telmisartan in diabetic rats WU Shi-
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ping CHEN Ming. Department of Cardiology Suining Central Hospital Suining 629000 China.
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Corresponding author CHEN Ming E-mail chenmingcq@ yahoo. com
【Abstract】 Objective To observe the influence of telmisartan on the vascular endothelium impairment in dia-
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betic rats and explore the preventive and therapeutic effect of it on vascular endothelium impairment of diabetes.
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Methods The diabetic model was established in rats which then were divided into groups and given different interven-
tions. The changes of morphology and function of the vascular endothelial cells were observed and all groups -
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pared. Results ①Compared with the normal group there were swelling necrosis and detachment of the