糖尿病性腔隙性脑梗死患者细胞黏附分子表达的观察.pdf

266 Chin J Clin Neurosci 2003, 11( 3) , 266~ 268
糖尿病性腔隙性脑梗死患者细胞黏附分子表达的观察
朱梅佳
曹莉莉
李秀华
孙钦建
山东大学临床学院山东省千佛山医院神经内科( 250014)
关键词
腔隙性脑梗死
糖尿病
CD11b/ CD18
CD62p
摘要
目的: 探讨血糖对黏附分子的影响及其在 LI 发病机制中的作用。方法: 采用流式细胞术对 LI 合并
型糖尿病及非糖尿病 LI
病人外周血白细胞的膜糖蛋白 CD11b、CD18 和血小板膜糖蛋白 CD62p 的表达进行检测。结果: 两组病人比较血小板膜糖蛋白
CD62p、白细胞膜糖蛋白 CD11b、CD18 表达在腔隙性脑梗死合并糖尿病组明显高于非糖尿病腔隙性脑梗死组; 血糖与 CD62p、CD11b
呈正相关; CD62p、CD11b、CD18 及血糖与 LI 腔梗个数无关。结论: 超负荷血糖时血小板、白细胞均处于高活化状态。超负荷血糖导
致的细胞黏附分子的高表达参与 LI 微血管病变的损伤过程。
The Effect on Expression of Adhesion Molecule in Patients of Diabetes with Lacunar Infarction
ZH U Mei
Jia, CAO Li
Li, LI Xiu
Hua, et al.
Neurological Department of Shandong Provincial Qianfoshan Hospital Attached to M edical College of Shandong University,
Shangdong, 250014, China
KEY WORDS
lacunar infarction
diabetes mellitus
CD11b/ CD18
CD62p
ABSTRACT
Aim: To investigate the influences of blood sugar on expression of adhesion molecules and its effects on pathogenesis related with
lacunar infarction ( LI) . Methods:The expressions of leucocytes membrane glycoproteins CD11b, CD18 and platelet membrane CD62p were mesured
in whole blood by flow cytometry ( FCM) in 30 LI patients with type
diabetes and 30 LI those without the diabetes. Results:The expression levels
of leucocytes membrane glycoproteins CD11b, CD18 and platelet membrane CD62p are significantly higher in LI with diabet