Chapter 5 summarization of Autonomic Nervous System Drugs.ppt

Chapter 5 summarization of Autonomic Nervous System Drugs第五章传出神经系统药理概论
TAISHAN medical university
zhangfeng
传出神经系统
植物神经系统(vegetative nervous system) [自主神经系统(autonomic nervous system)]:主要支配心肌、平滑肌和腺体等效应器。
运动神经系统:支配骨骼肌。
I. Anatomy(解剖学) and neurotransmitter(神经递质) chemistry of the autonomic nervous system
A. Cholinergic Fibers(胆碱能神经)
preganglionic efferent(传出的)autonomic fibers and somatic motor fibers
2. All parasympathetic postganglionic fibers
3. A few sympathetic postganglionic fibers
- sweat gland
- skeletal muscle vascular dilating nerves
4. The nerve innervate to adrenal medulla
B. Noradrenergic Fibers(去甲肾上腺素能神经)
Most of the sympathetic postganglionic fibers
Transmitter and receptor递质和受体
Acetylcholine,ACh(乙酰胆碱)→M1、M2、 M3、 M4、 M5; N1、N2 -receptor
cholinesterase ,AChE(胆碱酯酶)
Noradrenaline,NA(去甲肾上腺素)→α1、α2 ;β1 、β2 、β3 -receptor
uptake-1(neuronal uptake);uptake-2(non-neuronal uptake)[COMT,MAO]
Discover of transmitter
1921,Loewi的离体双蛙心灌流实验
提示迷走神经可释放一种抑制性物质,1926年证实为ACh。
Synapse
突触
乙酰胆碱的合成、释放、贮存和消除
NA合成、贮存、释放、消除基本过程