基质溶解素-1基因启动子多态性与急性心肌梗死的相关性.doc

基质溶解素-1基因启动子多态性与急性心肌梗死的相关性

【摘要】目的: 研究中国南方人群基质溶解素-1基因启动子1612 5A/6A多态性与急性心肌梗死的相关性。方法: 采用DNA测序法检测116例急性心肌梗死患者和105例对照的基质溶解素-1基因启动子序列。结果: ①基质溶解素-1基因启动子1612 5A/6A多态性的三种基因型(5A/5A、5A/6A、6A/6A)符合Hardy-Weinberg分布。②与对照组相比,心梗组的基质溶解素-1基因5A/5A和5A/6A基因型较多见,差异有显著性,P <。③基因型的相对风险分析发现,5A/5A或5A/6A基因型携带者患急性心肌梗死风险是6A/(95%可信区间:-)。结论: 基质溶解素-1基因启动子1612 5A/6A多态性可能与中国南方急性心肌梗死的遗传易感性相关联,5A等位基因是急性心肌梗死发病的一个独立危险因素。
【关键词】基质金属蛋白酶基因基因多态性急性心肌梗死危险因素
Abstract: Objective: To investigate the relationship between the polymorphism of 1 612 5A/6A in the promoter of the stromelysin-1 gene and the acute myocardial infarction (AMI) in population of southern Chinese. Methods: Using DNA sequencing,the polymorphism of the stromelysin-1 gene was detected in both 116 AMI patients and 105 control subjects. Results: ① The allelic distribution of the stromelysin-1 gene in both groups matched the Hardy-Weinberg equilibrium (P >).
② The number of 5A allele of the promoter of the stromelysin-1 gene in patients with AMI was higher than that of the control group (P <).③The odds ratio of the 5A/6A+5A/5A was (95% CI, to ). Conclusion: The 1612 5A/6A polymorphism in the promoter of the stromelysin-1 gene is associated with AMI in southern Chinese. The 1612 5A allele in the promoter of the stromelysin-1 gene may play an important role in the pathogenesis of AMI.
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