替硝唑口腔贴片治疗牙周炎的临床疗效及安全性.doc

替硝唑口腔贴片治疗牙周炎的临床疗效及安全性
DT"CLEAR:both"作者:吴军正,王勤涛,周威,温德升,王宝彦,常晓峰,张军,董金凤,夏结来/DT
DT"CLEAR:both"
STRONG【关键词】/STRONG替硝唑;牙周炎;临床试验
Efficacyandsafetyoftinidazoleadhesivetabletinthetreatmentofperiodontitis
【Abstract】AIM::Intherandomized,doubleblind,parallelgroup,controlledandmulticenterstudy,(TAT,5mg/piece)andthelatterwithoraltinidazoletablet(OTT,500mg/piece).algingivalsurfacefacingtothecheekbetweenevery2adjacentpremolarsandmolarsfollowingmouthwashingafterbreakfastandafterdinner(1piecepertooth,2/d).(2piecesperday,respectivelyafterbreakfastandafterdinner).(SBI),pocketdepth(PD),toothmobility(TM)andplaqueindex(PLI)weremeasured,subgigivalbacteriaflora(SBF)wasexamined,ests,:pletedin75and70casesintheexperimentalandcontrolg
,sex,upationinthe2groupswerenotsignificantlydifferent(P>).Beforetreatment,nostatisticdifferencewasfoundinSBI,PD,TM,PLI,SBFpositiveratesandSBF(CFU/mL)betweenthe2groups(P>).Aftertreatment,±±(P>),%%(P>),%%(P>),,PD,TM,PLIandSBFweredecreasedinbothgroups(P>,P<).%,thedrugrelatedadverseevent5%.,liverfunctiontestsandrenalfunctiontestswereinnormalrangebeforeandaftertreatm
:TATiseffectiveandsafeinthetreatmentofperiodont