TGF-β1和Ki67在原发性乳腺癌中的表达与临床意义.doc

TGF-β1和Ki67在原发性乳腺癌中的表达与临床意义
(作者:___________单位: ___________邮编: ___________)
【摘要】目的探讨TGF-β1和Ki67在原发性乳腺癌组织中的表达,探讨二者表达与原发性乳腺癌之间的关系,为临床评估和治疗乳腺癌提供参考依据。方法用免疫组化(SP)方法检测251例原发性乳腺癌组织中TGF-β1和Ki67的表达,并进行相关性分析。结果 TGF-%(138/251),%(181/251) 。Ki67表达与TGF-β1表达有关(P )。结论 TGF-β1信号通路的异常导致原发性乳腺癌细胞增殖异常,而表达为肿瘤细胞Ki67升高。联合检测TGF-β1和Ki67可能有助于原发性乳腺癌预后的判断。
【关键词】 TGF-β1;Ki67;原发性乳腺癌;免疫组化
[Abstract] Objective To observe the expression of TGF-β1 and Ki67 gene in primary breast cancer, investigate the correlation of TGF-β1,Ki67 in primary breast The expressions of TGF-β1 and Ki67 were dectected by immunohistochemistry in 251 cases of primary breast cancer tissue and the correlation of expression were analyzed.
Results The expression levels of TGF-β1, Ki67 in primary breast cancer tissue was %(138/ 251),%(181/ 251).The expressions of TGF-β1 in primary breast cancer tissue were associated with the expression of Ki67( ).Conclusion TGF-β1 can raise the expression of Ki67 in primary breast cancer tissue,detecting the expression of TGF-β1,Ki67 in primary breast cancer may be helpful to predict prognosis.
[Key words] TGF-β1;Ki67;primary breast cancer;immunohistochemistry
乳腺癌是西方工业化国家最常见的女性恶性肿瘤,近年来在我国的发病率有上升趋势。本文通过免疫组化SP法检测TGF-β1和Ki67在原发性乳腺癌组织中的表达情况,探讨二者表达与原发性乳腺癌的关系。
1 资料与方法
一般资料收集湖南省肿瘤医院腹部外科腹部外科2004 年2 月至2007 年2月保存的乳腺癌术后组织标本