α－干扰素和更昔洛韦治疗传染性单核细胞增多症的疗效比较.doc

α-干扰素和更昔洛韦治疗传染性单核细胞增多症的疗效比较
(作者:___________单位: ___________邮编: ___________)
作者:岑丹阳朱军薛红漫谢荣初
【摘要】目的比较α-干扰素(α-INF)和更昔洛韦(GCV)治疗儿童传染性单核细胞增多症(IM)的疗效。方法 222例儿童IM分为GCV治疗组(59例)、α-INF治疗组(74例)和其他药物(利巴韦林等)治疗组(89例),3组患儿年龄、性别、病程、病情等无明显差异。GCV治疗组给以GCV 10 mg/(kgd),1次/12 h,静脉滴注,7 d后改为5 mg/(kgd),1次/d,静脉滴注,总疗程10~14 d。α-INF治疗组给以α-INF 5万U/(kgd),肌内注射,总疗程10~14 d。结果 GCV治疗组和α-INF治疗组在热程、咽峡炎改善、淋巴结、肝脾开始缩小、异型淋巴细胞恢复至10%的时间等方面均优于其他药物治疗组,差异有显著性;而该两组之间上述各项指标改善的比较无统计学差异;②GCV治疗组4例出现粒细胞降低,α-INF治疗组11例出现发热,均在停药后3~7 d恢复正常。结论应用GCV及α-INF治疗IM均可取得明显疗效,GCV与α-INF之间的疗效比较并无明显差别,两种药物均无严重不良反应。
【关键词】儿童;传染性单核细胞增多症;
α-干扰素;更昔洛韦

【Abstract】 Objective pare the therapeutic effect of GCV and α-interferon to infectious mononucleosis (IM) in 222 patients were divided into the ganciclovir(GCV) treatment group (n=59),the α-interferon treatment group (n=74) and the control group (n=89).Among these three groups there were no differences in age,sex and patients, in the GCVgroup were given GCV 10 mg/(kgd),q12 h,iv drip for 7 days,then 5 mg/(kgd),qd,iv drip,the whole treatment course were 10-14 in the α-interferon group were given α-interferon 5×104U/(kgd),im,for 10-14 control group were given other drugs(ribavirin,etc).Results ①Between the GCV group and the control group,significant difference were found in the shorten of fever duration,the improvement of the angina,the dimin