轮状病毒腹泻患儿心脏损伤的相关因素.doc

轮状病毒腹泻患儿心脏损伤的相关因素
【关键词】轮状病毒属
关键词:轮状病毒属;感染;心脏;病毒血症
摘要:目的为了了解轮状病毒(RV)腹泻患儿心脏受累的可能性以及与临床表现及病毒血症等相关因素的关系. 方法检测RV腹泻患儿44例血清心型激酶(CK-MB)、谷草转氨酶(AST)值,并将CK-MB的变化与相关临床表现等进行多因素分析;以反转录-套式PCR方法检测RV腹泻组患儿外周血血清和单个核细胞中的RV基因组. 结果 RV腹泻患儿44例中,CK-MB异常者25例(57%),其中22例(50%)为282~498nkat・L-1 ,3例(7%)为650~1300nkat・L-1 ;AST异常者36例(82%),其中24例(55%)为783~1466nkat・L-1 ,4例(9%)为1510~2075nkat・L-1 ,7例(16%)为2633~6800nkat・L-1 .腹泻、脱水与酶学增高无显著相关,,其中血浆中1例,外周血单个核细胞中3例. 结论在RV腹泻普通人群中也可能出现肠道外感染,.

Keywords:rotavirus;infection;heart;viremia

Abstract:AIM To investigate the possibility of myocardial involvement in children with rotavirus(RV)diarrhea and its association with c
linical manifestations and viremia resulting from RV Levels of creatine kinase-MB(CK-MB)and aminotranferase(AST)in the serum of children with RV diarrhea were measured and multi-factor analysis was performed to explore the correlation between changes in CK-MB level and the clinical genome of RV from blood serum and mononuclear cells were tested with reverse-nest polymerase chain -SULTS For CK-MB,out of the44children with RV diar-rhea,25(57%)were observed abnormal in terms of the serum of these25cases,the values of22(ac-counting for50%of the total cases)ranged from282nkat・L-1 to498n