早期乳腺癌辅助化疗进展.ppt

早期乳腺癌辅助化疗进展BreastCancerIncidenceTrendsOverTimeCancerIncidenceTrendsinChina2019–2019IncidenceRatesProjectionbyCancerTypePer100,%%%CAGR–%%%Source:EstimatesofCancerIncidenceinChinafor2000andProjectionsfor2019,YangL,:,000;死亡率:,000发病率:城市>农村高发年龄段:45-50岁近15年来乳腺癌发病率上升死亡率下降死亡率下降的原因早期诊断综合治疗ThebenefitsofchemotherapydatafromclinicaltrailsEarlyBreastCancerTrialists'CollaborativeGroup(EBCTCG).194randomisedtrialsofadjuvantchemotherapy(CMF,CAF,CEF)orhormonaltherapy(TAM)%(years)051510Recurrence(%)15-%()Log-rank2p<-yearprobabilitiesofrecurrenceinwomenaged<50years,with/%,35%node-positive;olderwomen,70%node-positive;SE=;365:1687-%cancermortality(%)15-%()Log-rank2p<%Time(years)-yearprobabilitiesofbreastcancermortalityinwomenaged<50years,with/;365:1687-1717Youngerwomen,35%node-positive;olderwomen,70%node-positive010203040506015-%()Log-rank2p<%%-yearprobabilitiesofrecurrenceinwomenaged50-69years,with/withoutpolychemotherapyTime(years);365:1687-1717Recurrence(%)Youngerwomen,35%node-positive;olderwomen,70%node-positive