小儿慢性乙型肝炎临床与肝纤维化病理的有关特征.doc

小儿慢性乙型肝炎临床与肝纤维化 病理的有关特征        【摘要】目的分析我国小儿慢性乙型肝炎临床与肝纤维化病理的有关特征。方法对66例小儿慢性乙型肝炎患者常规进行甲、乙、丙、戊型肝炎病毒血清学检测、肝功能检查及肝穿病理组织检查。结果年龄、病程、起病方式在无纤维化组(S0组)和明显肝纤维化组(≥S3)间经统计学处理差异无显著性意义;%,≥%;S0组HBeAg阳性率明显高于≥S3组(%%);肝脏炎症活动度越高纤维化程度越重。结论小儿慢性乙型肝炎肝纤维化与年龄、病程、起病方式及乙肝病毒复制无关,与肝脏炎症活动度成正相关。小儿慢性乙型肝炎患者出现脾大、凝血酶原活动度异常、血清白蛋白下降及γ-球蛋白升高,应高度警惕肝纤维化。【主题词】肝硬化; 肝炎,乙型; 临床试验; 儿童,住院ThecharacteristicsofclinicalcourseofchronichepatitisBandlivercirrhosispathologyofchildpatientsMAYuzhi ZHANGHongfei PIAOMingshu etal(DepartmentofInfectiousDiseases,panyofChemicalIndustry,Jilin132002,China) 【Abstract】 Objective TheserumtestforhepatitisA/B/C/E, Theage,clinicalcourseandformofdiseaseonset,showednoobviousdifferencebetweenS0group(withoutlivercirrhosis)andgroup≥S3(withevidentlivercirrhosis).%inS0group,%ingroup≥≥S3(%%respectively).Thehighertheactivityofliverinflammation, ThelivercirrhosisofchildpatientswithchronichepatitisBhasnothingtodowiththeirage,clinicalcourse,formofdiseaseonsetandvirusreplication,butitisindirectconnectionwithth