膀胱癌的血管内皮细胞生长因子表达、微血管计数及其临床意义.doc

膀胱癌的血管内皮细胞生长因子表达、 微血管计数及其临床意义        【摘要】目的寻求与膀胱移行细胞癌预后相关的新诊断方法。方法以SABC免疫组化及亲和组化法研究83例膀胱移行细胞癌的血管内皮细胞生长因子(VEGF)表达、微血管计数及其与病理分级、预后的关系。结果 VEGF表达强度、微血管计数在Ⅲ与Ⅰ级癌间、在有复发、转移及5年死亡组与无复发、转移组间有极显著性差异(P<)。VEGF表达、微血管计数在Ⅲ级癌组、在有复发、转移及5年死亡组有相关性。结论 VEGF是血管形成的重要因子,VEGF高表达、微血管计数高是辅助预测膀胱癌患者预后不佳的新指标。【关键词】膀胱肿瘤癌免疫组化新血管形成ExpressionofVEGFandmicrovesselcountsinbladdercancerandtheclinicalimplicationZhaoGuofan*,SunRui,LiuWuying,,TianjinMedicalUniversity,Tianjin300203 【Abstract】(SABC),theexpressionofvascularendothelialgrowthfactor(VEGF)andtumorangiogenesiswerestudiedonarchivalspecimensof83casesofhumanbladdertransitionalcellcarcinomaand6casesofnormalbladdermucosa,ⅢandgradeⅠcarcinoma,ormetastatic,recurrent,5-yeardeathgroupandthegroupwithoutmetastasisandrecurrence(P<).TheexpressionofVEGFwascorrelatedwithmicrovesselcountsingradⅢcarcinomaorincasesofmetastasis,recurrence,5-yeardeath(P<).ConclusionVEGFisanimportantangiogenicfactor,andhighexpressionofVEGFandmicrovesselcountsmayaidinpredictingatriskformetastasis,recurrenceand5-yeardeath. 【Keywords】BladderneoplasmsCarcino