石墨烯复合材料的合成及其在内源性肽段富集中的应用.doc


Facile Preparation of ic Graphene Double-sided
posites for the Selective Enrichment and
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10
15
20
Analysis of Endogenous Peptides#
LI Yan1, YIN Peng2, DENG Chunhui2**
(1. Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University,
ShangHai 201203;
2. Chemistry Department, fudan University, ShangHai 200433)
Abstract: In this work, ic graphene double-sided mesoporous posites
(mag-******@mSiO2) were synthesized by coating a layer of mesoporous silica materials on each
side of ic graphene. The surfactant (CTAB) mediated sol-gel coating was performed using
TEOS as the silica source. The as-made ic graphene double-sided mesoporous posites
were treated with high-temperature calcination to remove the hydroxyl on the surface. The novel
double-sided materials possess high surface area ( cm2/g) and large pore volume ( cm3/g). The
highly open pore structure presents uniform pore size ( nm) and structural stability. The
hydrophobic interior pore walls could ensure an efficient adsorption of target molecules through
hydrophobic-hydrophobic interaction. At the same time, the ic Fe3O4 particles on both sides of
the materials could simplify the process of enrichment, which plays an important role in the treatment
plex biological samples. The ic graphene double-sided posites were
essfully applied to size-selectively and specifically enrich