::U1**********ANZCTRNumber:<<toinsert>>HDECApprovalNumber:<<toinsert>>Funding:HRCpartnershipgrantinconjunctionwithMRINZInvestigators:GerogeBardsleyMichaelRichardsPipShirtcliffeJaninePilcherMarkHollidayMarkWeatherallRichardBeasleyContact:DrJaninePilcherMedicalResearchInstituteofNewZealandPrivateBag7902,Wellington,NewZealand,Telephone:+64-4-8050241Facsimile:+64-4-4729224,Email:janine.******@(COPD)resultinover9,000hospitaladmissionseveryyearinNewZealand(NZ).(RCT)inwhichhighconcentrationoxygentherapy(supplementaryoxygen8-10L/minandhighflowoxygen-drivennebulisersforbronchodilatordelivery)-paredwithtitratedoxygentherapy(supplementaryoxygentitratedasneededtoachieveanoxygensaturationof88-92%andair-drivennebulisersforbronchodilatordelivery),anelevatedarterialcarbondioxidetension(PaCO2),isaknownriskofhighconcentrationoxygentherapyinpatientswithCOPD,34andoxygendrivennebuliserusehasbeenassociatedwithmarkedincreasesinPaCO2,whichresultedinstupor,-7TheBritishThoracicSociety(BTS)mendstitratedoxygentherapytoachieveoxygensaturationsof88-92%andair--drivennebulisersareunavailable,-drivennebuliserswillpreventtheincreaseinPaCO2thatresultsf
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