前列腺体积对前列腺特异抗原的影响.doc

前列腺体积对前列腺特异抗原的影响        摘要:目的:研究前列腺特异抗原(PSA)与前列腺增生腺体体积的关系及其在前列腺癌(PCa)诊断中的价值。方法:75例前列腺增生症(BPH)患者根据其PSA>或≤4μg/L分为两组,另有25例PCa患者,术前用放射免疫法测定血清PSA。所有患者经B超测出前列腺体积,用t检验和相关分析研究各组间的差异及相关性。结果:PSA>4μg/L的BPH较之PSA≤4μg/L者,腺体体积显著增大且PSA和PSA密度(PSAD)显著增高。整个BPH组PSA和前列腺体积之间存在显著相关性,其中PSA>4μg/L者却没有这种相关性。结论:一部分BPH由于腺体增大和其他干扰因素使PSA增高,且PSA与前列腺体积失去相关性,影响了PSA和PSAD的诊断准确性。关键词:前列腺肥大前列腺特异抗原前列腺肿瘤ProstatespecificantigenandprostateglandvolumeLIUNan-song XIZu-wei(DepartmentofUrology,,Shanghai,200060)SHAOYuan ZHANGZu-bao(DepartmentofUrology,RuijinHospital,ShanghaiSecondMedicalUniversity)Abstract:Purpose:Tostudytherelationshipbetweenprostatespecificantigen(PSA):ThesrumPSAlevelsandprostatevolumein75casesofbenignprostatichyperplasia(BPH)and25casesofprostatecancer(PCa):WhenPSA>4μg/L,prostatevolume,PSAandPSADofBPHwereallsignificantlyhigherthanBPHwithPSAlessthanorequalto4μg/,butitlostwhilePSA>4μg/:SerumPSAlevelsrasieofsomeBPHraiseduetolargerprostatevolumeandotherreasonsandPSAlostitscorrelationwiththevolume,thisinfluencetheusageofPSA,:Prostatichypertorophy Prostatespecificantigen eoplasmas▲前列腺特异抗原(PSA)是目前常用的前列腺癌(PCa)筛选诊断指标,但一部分前列腺增生症(BPH)患者与PCa患者的