儿童急性淋巴细胞白血病的治疗.doc

儿童急性淋巴细胞白血病的治疗.doc儿童急性淋巴细胞白血病的治疗儿童ALL化疗:见下表(BFM-ALL90)表1-治疗协议治疗方案单一或每日剂量约定□期诱导协议I阶段A泼尼松(口服)60mg/m2每U1-28f长春新碱(IV)(最大,2mg)8,15,22,29柔红霉素(IV)30mg/m28,15,22,29L・天门冬酰***酶(IV)10000IU/m212,15,18,21,24,27,30t,33|氨甲蝶吟(IT)12mgt1,15,29阶段B(仅限标危组和屮危组)环磷酰***(IV)1000mg/m236,64阿糖胞廿(IV)75mg/m2perday38-41,45-48,52-55,59-626筑基瞟吟(orally)60mg/m2perday36-64氨甲蝶吟(IT)12mg#45,59巩固(在标危组和中危组中)协议M6■毓嚓吟(orally)25mg/m2perday1-56氨甲蝶吟(24-小时输注)§5g/m28,22,36,50氨甲蝶吟(IT)12mgt8,22,36,50协议M-A1JL■天门冬酰***酶(IM)25000IU/m210,24,38,52再诱导(在标危组和屮危组)协议III地塞米松(orally)10mg/m2perday1-21长春新碱(IV)(max,2mg)8,15,22,29阿霉素(IV)30mg/m28,15,22,29L■天门冬酰***酶(IV)10000IU/m28,11,15,18环磷酰***(IV)1000mg/m236阿糖胞廿(IV)75mg/m238-41,45-486■硫鸟嚓吟(orally)60mg/m236-49氨甲蝶吟(IT)12mgt38,45强化再巩同(仅限高危组)要素HR・1地塞米松e(orally)20mg/m21-56•疏嚓吟(orally)100mg/m2perday1-5Vincristine(IV),5氨甲蝶吟(24-hrinf)§5g/m21阿糖胞昔(3・hrinf)2g/m2(singledose)5(twice,12-hrinterval)L■天门冬酰***酶(IM)25000IU/m26氨甲蝶吟/阿糖胞廿/泼尼松龙(IT)12mg/30mg/10rngt1要素HR・2地塞氷松(orally)20mg/m21-5硫鸟嚓吟(orally)100mg/m2perday1-5长春地辛(IV)3mg/m21氨甲蝶吟(24-hrinf)§5g/m21异环磷酰***(1-hrinf)400mg/m2perday1-5柔红霉素(24-hrinf)50mg/m25L•天门冬酰***酶(IM)25000IU/m26氨甲蝶吟/阿糖胞昔/泼尼松龙(IT)12mg/30mg/10rngt1要索HR・3地塞氷松(orally)20mg/m21-5阿糖胞甘(3・hrinf)2g/m2(singledose)1,2(4times,12-hrnterval)足叶乙貳(1-hrinf)150mg/m2perday3-5L■天门冬酰***酶(IM)25000IU/m26氨甲蝶吟/阿糖胞昔/泼尼松龙(IT)12mg/30mg/10mgt5IV指的是静注;max,最多;IT,intrathecal;SRG,标危组;MRG,中危组;inf,输注;IM,肌注;HRG,、巩固和再诱导,约定的日期是治疗的时间顺序