疏水过滤器完整性测试讲解.pdf

Hydrophobic Integrity Testing 疏水性过滤器完整性测试过滤/完整性测试培训课程 What you will learn 主要内容?The types of particles and anisms used for testing hydrophobic filters 测试疏水性滤膜所用的颗粒及微生物的种类?How we can test hydrophobic filters with the same liquid properties we used to test hydrophilic filters 如何利用测试亲水性滤膜的液体来测试疏水性滤膜?What new tests are available to address the limitations of alcohol based testing –HydroCorr 新的测试方法可以去除使用酒精---Hydrocorr ?How and when to use HydroCorr to it’s maximum advantage 如何及合适使用Hydrocorr方法更能体现其优点 Particle Based Integrity Testing 测试所用的颗粒? anism -Destructive Test ?微生物测试---破坏性测试– Aerosol anisms or liquid bacterial challenge –气雾型微生物或者使用液状细菌进行挑战– Phage (T1, T3, phiX)噬菌体– Bacteria (B. diminuta) 细菌(缺陷型假单孢杆菌) ? Aerosol Based -Non-destructive Test ?气雾测试----非破坏性测试–"Smoke" (., Glycerol, Corn oil, etc) 烟雾– Methylene Blue, Sodium Flame 亚***蓝,钠火焰– Issues注意点?Particle Distribution must be uniform颗粒分布必须是均一的?Must have correlation of particles vs anisms ?颗粒与微生物之间需要有相关性?High equipment cost设备成本高?Difficult to perform in-situ很难在线测试 Traditional Testing Principles 传统测试原理?Typical wetting liquids are Isopropyl Alcohol (.), Methanol, Tert-butyl Alcohol, or a mixture of one of these and water ?典型的润湿液是异丙醇,甲醇或他们与水的混合物?Uses same principles as a hydrophilic test ?使用与亲水性滤膜测试相同 pressed air Alcohol / Water Gas Flow Curve 酒精/水气体流速曲线–Don't use 100% solvent, check gauges, set pressure accurately, check for correct test gas, look for distinctive change in gas flowrate –不要使用100% Alcohol Testing Advantages 用酒精测试的优点?No special equipment required 不需特定的设备?Follows similar procedures to hydrophilic membranes. Operator training time is reduced . ?Traditional 是传统的方法?Widely accepted 广泛被接受?Well understood 很好理解?Correlated to bacterial challenge与细菌挑战有相关性?Can be performed easily & quickly 能非常容易及快速的进行测试 Alcohol Testing Issues 采用酒精测试的问题? Alcohol / Water mixtures are often used due to: 酒精/水的混合物使用经常会导致?Cost成本高?Flammability有燃烧的危险?high diff