皮肤性病学英文陈爱军带状疱疹英文教学.pptx

Definition
Herpes zoster is caused by
Varicella - Zoster virus (VZV) ,
classically occurs unilaterally within
the distribution of a sensory nerve,
being characterized by clustered
vesicles and considerable neuralgia.
Pathogen and Pathogenesis
Pathogen
Varicella-Zoster virus (VZV) is
characterized by neurotropism and
dermatotropism.
Pathogenesis
VZV causes varicella in childhood , and
establishes latency in sensory ganglia
after the primary infection. VZV may
replicate later in life, taking advantage
of the decline in immune function,
traveling down the sensory nerve into
the skin , showing neuralgia and
clustered vesicles.
Clinical manifestations
Prodrome:
headache and fever
hyperaesthesia
pain in the affected area.
Features of lesions
The eruption presents as papules and erythema in the dermatome.
Over a few days, crops of clustered red papules form in a discontinuous band and quickly evolve to clear vesicles surrounded by erythema.
The eruption may have few
lesions or reach total confluence
in the dermatome.
Lesions may become
hemorrhagic, necrotic, or bullous.
The vesicles slowly become pustulars,
and rupture to form crusts , which
separate in two to four weeks, often
with scarring.
The regional lymph nodes are
enlarged and tender.
Complications
Postherpetic neuralgia(PHN)
The pain persists after the skin
lesions have healed, with the same
quality as that of acute zoster pain.
>a month
Ophthalmic Zoster
Ocular involvement is most
commonly in the form of uveitis
and keratitis.
Ramsay Hunt syndrome
Results from involvement of the facial and aud