缺氧预处理对模拟失重大鼠比目鱼肌萎缩预防.doc

缺氧预处理对模拟失重大鼠比目鱼肌萎缩的预防
缺氧预处理对模拟失重大鼠比目鱼肌萎缩
的预防
第19卷第4期
2006年8月
航天医学与医学工程
SpaceMedicine&MedicalEngineering

缺氧预处理对模拟失重大鼠比目鱼肌萎缩的预防
王玉.,李华凤,杨沛,蒲劲松.,刘彦娜,邓文骞.,左天香.
(,四川成都610041;,四川成都610041)
摘要:
吊法建立模拟失重动物模型,将雌性SD大鼠按体重配对原则随机分为对照组(CON),尾部悬吊组
(SUS)及缺氧预处理+尾部悬吊(HCP4-SUS),对HCP4-SUS组进行l周的缺氧预处理.
处理完成后,将SUS及HCP4-,取双后肢比目鱼
肌,,取上清液用于超氧化物歧化酶(SOD),丙二醛(MDA)的检
,SUS组大鼠双后肢比目鱼肌湿重明显低于CON及HCP4-SUS组(P<0.
01).与SUS组相比,HCP4-SUS组比目鱼肌SOD活性明显升高(P<),MDA水平明显降低(P
<).结论缺氧预处理可提高大鼠骨骼肌的抗氧化能力,对失重状态下发生的
骨骼肌萎缩有预防
作用.
关键词:失重模拟;缺氧预处理;尾吊;比目鱼肌;肌萎缩
中图分类号::A文章编号:1002-0837(2oo6)04-0269-0272
PreventiveEffectsofHypoxicPreconditioningonRatSoleusMuscleAtrophyInducedbvSimulated
,LIHua—feng,YANGPei,PuJin—song,LiuYan—
na,DENGWen—qian,
ZOUTian—&MedicaIEngineering,2oo6,l9(4):269—272
Abstract:ObjectiveTofindoutwhetherhypoxicpreconditioning(HCP)hadapreventiveeffecton
—
suspensionmode1
wasestablishedconsistingof60femaleSDratswhich,accordingtopairingbybodyweight,were
randomlydividedinto3groupsofcontroI(CON),tail—
suspension(SUS),andhypoxicprecondition—
ingPIustail—
suspension(HCP4-SUS).TheratsoftheHCP4-SUSgroupwerepretreatedforone %O,. theratsoftheSUSandHCP4- groupsofratswereexecutedandthesoleusmusclesoftheIrhindlimbsweredissectedand weighedrespectivelypost—
—
natefordetectingactivitiesofthesuperoxidedismutase(SOD)andcontentsofthemalondialde—
hyde(MDA).ResultIthadbeenfoundthat,aftertwo—weektail—
suspension,wetweightsofhind—
IimbsoleusoftheratsinSUSgroupdecreasedobviouslyascomparedwiththoseoftheratso