新型口服对比剂茶在MRCP中的临床试用.docx

新型口服对比剂茶在 MRC呻的临床 试用
【摘要】 目的 评价一种新型口服对比 剂--茶叶为原料研制的磁共振口服阴性对 比剂在腹部MRC衿断中的价值和可行性， 为临床MRC检查应用提供一种理想对比剂， 以进一步促进 MRC脸查的发展。 方法 以 水为参照物，将不同浓度的茶对比剂置于磁 共振中进行同一序列的扫描， 比较不同浓度 的茶对比剂对成像信号的影响。 在相同情况 下选择17例志愿者对口服茶对比剂前后进 行MRC戚像，对检查结果进行分析、综合。 结果 不同浓度的茶对比剂产生不同的信号， 清晰度不同，经体外试验确定最佳浓度的茶 中，镒的浓度为土 /L。此浓度下的茶对比剂， 信号与水相反，即T1高信号，T2低信号。 MRC眦像抑制了胃、十二指肠道内的液体高 信号，使胰胆管周围背景干净，突出胰胆管 内的液体高信号成分，图像质量显着性提高 (p <)。结论 茶作为天然饮品，服用后安 全，无毒副作用，对胃肠道无刺激，在肠腔
内不发酵，不产生气体，充盈肠腔充分，保 证肠腔内信号均匀一致。利用茶叶中镒的特 性将茶作为磁共振
MRC脸查口服阴性对比 剂，不需要经过药物试验即可应用。 在MRCP
检查中应是一种理想的口服对比剂。
【关键词】 茶叶对比剂MRCP信号强度
信噪比(SNR)
[Abstract] Objective To evaluate the efficacy of a kind of Chinese tea (Rizhao green tea) administration as an oral negative contrast agent for magnetic resonance cholangiopancreatography (MRCP) studyso as to provide an ideal negative contrast agent which is natural, safe, inexpensive and palatable; and to assist MRCP analysis for further development of. Methods MR imaging of phantoms comprising cylinders of tea at various concentrations and water as a control were performed under the identical scanning sequence to compare the effect of tea concentration on the
image signal. MRCP was subsequently performed in 17 selected volunteers, before and after ingestion of tea.
Quantitative and qualitative comparison between pre- and post-tea oral administration was obtained systematically. Results The various tea concentrations resulted in different outcomes in terms of signal intensity and clarify. High manganese concentration of mg/L was detected in the optimum tea dosage. In contrast to water, tea decreased the T2 relaxation time of the fluid in the stomach and duodenum. The intraluminal signal of the gastrointestinal tract on T2W imaging was reduced, due to the paramagnetic properties of high manganese content in tea. There was statistically significantly (p ) improvement in conspicuity of the common bile duct and main pancreatic duct after tea ingestion.
Conclusion Tea ,as a natural drinking ,is safe, no side effect, no irr