Lecture 6 Biodegradable Polymers for Tissue Engineering.pdf

Molecular Principles of Biomaterials Spring 2003
Lecture 6: Biodegradable Polymers for Tissue Engineering
Last time: enzymatic degradation of solid polymers
Engineering biological recognition of polymers
Today: Designing polymers for tissue engineering
Reading: ‘Tissue engineering- current challenges and expanding opportunities,’ . Griffith and G.
Naughton, Science 295, 1009 (2002)
Overview of Biomaterials in Tissue Engineering
Let’s review the main approaches and applications in Tissue Engienering before getting into the details of materials for TE
We will review the fundamental approaches that have been taken here and return to this topic later when we discuss
integration of biological molecules in synthetic biomaterials
• TE scaffolds seek to provide a surrogate for natural ECM
o Provide functions of native ECM
o Create a space for new tissue development
o Deliver cells to site
o Direct macroscopic size/shape of new tissue
Tissue Engineering Approaches
• 3 major approaches
o In vitro tissue genesis → in vivo application
o In vivo tissue genesis → in vivo application
parison of in vitro and in vivo tissue engineering approaches1:
Skin: bone:
Lecture 6 – Biodegradable Polymers in Tissue Engineering 1 of 5
Molecular Principles of Biomaterials Spring 2003
o In vitro tissue genesis → ex