磷酸化蛋白质组学文献3.pdf

Article

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Magnetic ******@ZrO2 Microspheres with Yolk Shell Structure:
Designed Synthesis and Application in Highly Selective Enrichment
of Phosphopeptides
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Wan-Fu Ma, , Cheng Zhang, , Yu-Ting Zhang, Meng Yu, Jia Guo, Ying Zhang, Hao-Jie Lu,*,
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and Chang-Chun Wang*,
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State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Laboratory of Advanced
Materials, Fudan University, Shanghai 200433, China
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Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
*S Supporting Information
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ABSTRACT: Magnetic yolk shell ******@ZrO2 microspheres
consisting of a movable magnetic supraparticle (MSP) core
and a crystalline ZrO2 shell were synthesized via a two-step
controlled “sol−gel” approach for the first time. First, a large
fi fi
amount of the generated hydrolyzate Zr(OH)4 was rmly xed
onto the surface of the cross-linked polymethylacrylic acid
matrix via a strong hydrogen-bonding interaction between
Zr(OH