甲状腺肿瘤的病理诊断与分析.doc

甲状腺肿瘤的病理诊断与分析.doc甲状腺肿瘤的病理诊断与分析
【摘要】目的：分析甲状腺肿瘤的病理分布特征，评价不同免疫组 化定性诊断良恶性肿瘤的效用。方法：选择医院2011年2月-2014年4月 收治的甲状腺结节患者190例作为研究对象，所有患者均经超声扫查、穿 刺活检诊断，术后获取标本，进行镜检病理学检查、免疫组化，病理科医 师与超声医师共同进行病理诊断。结果：%,甲状腺结节 肿瘤占57. 45%,%,%,其中乳头癌占 %,%,髓样癌占0. 70%,%,其中乳 头癌中经典型占55. 00%,%,%,嗜酸细胞 性0. 83%；乳头癌CK19表达阳性率高于其他肿瘤，比较差异有统计学意义 (P<0. 05)；良性肿瘤hTERT、Ki67、VEG、Ret、P53表达阳性率低于恶性 肿瘤，比较差异均有统计学意义(P<)o结论：甲状腺肿瘤手术患者 恶性肿瘤比重较高，其中多见乳头癌，乳头癌中不经典类型比重较高，免 疫组化是定性诊断甲状腺肿瘤的重要方法，采用多种恶性肿瘤基因组化可 提高诊断效用。
【关键词】甲状腺肿瘤；病理诊断；免疫组化
[Abstract] Objective： To analyze the pathological distribution characteristics of thyroid tumor and to evaluate the utility of different immunohistochemical qualitative diagnosis for benign and malignant tumors. Method： 190 patients with thyroid nodules in the
hospital from February 2011 to April 2014 were selected as the research objects. All patients were diagnosed by ultrasound scan and aspiration biopsy. Postoperative specimens were used for microscopy pathology examination and immunohistochemical. Pathological diagnosis was conducted by pathologists and ultrasound doctors. Result： Benign tumors accounted for 24. 74%, swollen thyroid nodule accounted for % , thyroid adenoma accounted for 42. 55%. Malignant tumor accounted for 75. 26%, including papillary carcinoma 83. 92%, follicular carcinoma 11. 89%, medullary carcinoma 0. 70% , und iff erent i