secretion of a chemotactic substance(s) by age-stimulated human monocytes开题资料.pdf

Diabetes Research arld Clinical Practice, 16 (1992) 7-11
0 1992 Elsevier Science Publishers . All rights reserved 016%8227/92/$ 7
DIABET 00611
Secretion of a chemotactic substance(s) by AGE-stimulated
human monocytes
Michael Z. Gilcrease and Richard L. Hoover
Department of Pathology, Vanderbilt University, Nashville. Tennessee,
(Received 13 May 1991)
(Revision accepted 1 November 1991)
Summary
Receptors for products of non-enzymatic glycosylation have been identified previously on activated
human monocytes. In this study we have found that medium conditioned by activated human monocytes
following stimulation with AGE-BSA elicited an almost 3-fold greater chemotactic response from other
activated monocytes than conditioned medium obtained following stimulation with control B SA (44 2 13
and 16 + , respectively; n = 9, P < ). The response elicited from AGE-BSA alone was not
statistically significant. It appears that stimulation of the cells via the AGE-receptor results in the
secretion of increased levels of a chemotactic substance(s) for monocytes/macrophages. This mechanism
may help to explain the p