慢性阻塞性肺疾病痰瘀阻肺证大鼠模型的评价.pdf

第十一次拿国中西医结合防治呼吸系统疾病学术研讨会论文集论文交流慢性阻塞性肺疾病痰瘀阻肺证大鼠模型的评价李泽庚,王传博,彭波,童佳兵,杨程,刘志刚(安徽中医学院第一附属医院,合肥,230031) 【摘要】目的:对已建立的慢性阻塞性肺疾病痰瘀阻肺证火鼠模型的可信性作出评价。方法:建立大鼠慢性阻塞性肺疾病痰瘀阻肺证模型,观察硝苯地平、芪白平肺胶囊对模型动物一股情况、肺功能、肺动脉压、右心肥厚指标和病理结果等的影响。结果:模型人鼠的一般情况、肺功能、肺动脉压、右心肥厚指标和病理结果筲改变均符合慢阻肺痰瘀阻肺证的病理特点。芪白平肺胶囊可显著改善模型人鼠气虚痰阻血瘀状况,明显改善其肺功能,降低肺动脉高压及右心肥厚指标等。结论:用本实验方法建立慢性阻塞性肺疾病痰瘀阻肺证人鼠模型是可行的。【关键词】慢性阻塞性肺疾病,痰瘀阻肺证,模型评价 Appraisal of ratmodel ofchronic obstructive pulmonary disease with phlegm obstructing lung syndrome WANG Chuan—bo,PENG Bo,LIZe—geng,TONG Jia—bing,YANG Cheng,LⅣZhi—gang (The FirstHospital Affilated toAnhui Hospital ofTCM,Hefei 23003 1,China) Abstract:Objective:Evaluate credibility ofestablished rat model of chronic obstructive pulmonary disease with phlegm obstructing :Establish ratmodel of chronic obstructive pulmonary disease withphlegm obstructing lung syndrome,Observe the impact of Nifedipine,Qi BaiPingfei capsule on General Situation ofratmodel,Lung function, Pulmonary arterialpressure,Right ventricular hypertrophy index and :The change of General Situation ofratmodel,Lung function,Pulmonary arterialpressure,Ri曲t ventricular hypertrophy index andPathology are allinlinewithpathological features ofchronic obstrucdve pulmonary disease withphlegm obstructing lung BaiPingfei capsule Call significantly improve thesituation ofqideficiency and blood stagnancy of ratmodel, si