NSCLC患者P53蛋白异常表达与铂类化疗敏感性的Meta分析.pdf

艟\ 、徽/^陌TBM·2007·BEiJING·CHINA Significance ofp53 protein pression‘patients with Np53 protein exPresslon inpatients with 0n. Small CellLung Cancer on chemosensitivity tocisplatin: AMeta--Analysis WANG Jin—liang,JIAO Shun-chang,LENG Peng,LI Jin-yu Department ofMedicalOncoiogy,General Hospital ofPLA,Beijing 00853,China. Toevaluatethesignificanceofp53 proteinexpression patients withNon·Small Cell Lung Cancer on chemosensitivity Arandom effect model by DerSimonian andLaird was applied toanalyze relevant Sixteen trialsinvolving 070patients were overall positive rateofp53 was %and overallresponse rate tocisplatin %.Testforheterogeneity showed that eligible studies were withheterogeneity(x2=,P<).bined oddsratio(OR)was 95%confidence interval was - Expression ofp53protein patients Cell Lung Cancer notassociated withthechemosensitivity tocisplatin. Keywords:NSCLC;P53;cisplatin;chemosensitivity: NSCLC患者P53蛋白异常表达与铂类化疗敏感性的Meta分析 VV汪进良,焦顺昌,李瑾昱(中国人民解放军总医院肿瘤内科,北京1 00853) 摘要:目的探讨NSCLC中P53蛋白表达与对铂类化疗敏感性的关系。方法应用Meta分析 Dersimonian·Laird分析模型对有关NSCLC中P53蛋白表达与对铂类化疗敏感性的文献进行综合定量评价。结果入选16篇文献共1070例患者,p53阳性患者539例,%。铂类化疗有效患者 414例,%。异质性检验显示x2=,P<,文献具有异质性,采用随机效应模型 Dersimonian—Laird法进行分析,合并优势比(OR),95%-。结论NSCLC中P53 蛋白阴性表达患者对铂类