2010全国生物材料大会论文集之 (515).pdf

Synthesis of Novel Glycyrrhetinic Acid Analogues
Yan-Qiu Meng Xiang-Lei Wang, Yan-Ling Song , Feng-Qing Li
Department of Pharmaceutical Engineering Department of Pharmaceutical Engineering
Shenyang University of Chemical Technology Shenyang University of Chemical Technology
Shenyang,China Shenyang, China
mengyanqiu@ wxls929@


Abstract—Glycyrrhetinic acid (GA, 3β-hydroxyl-11-oxo-olean- condensed with the appropriate pound such as
12-ene-29-oic acid, 1) isolated from Glycyrrhiza glabra was found cyclohexylamine, 2-aminopropanol, 3-aminopropanol, in the
to have several pharmacological activities. A series of novel GA presence of triethylamine to give pounds 7a–7c.
derivatives were designed and synthesized as antitumor agents.
1
Their structures were confirmed using MS and H-NMR. B. Spectrum Analysis
Keywords-Glycyrrhetinic acid; derivatives; designed; Synthesis The structures of all pounds were determined by
application of melting points, mass spectra and 1H-NMR
spectral data. The structure assignment pounds 4c and
I. INTRODUCTION 7a were supported paring the 1H-NMR. The 1H-NMR
Glycyrrhetinic acid 1 (3β-hydroxyl-11-oxo-olean-12-ene- spectrum pound 4c displayed an added methyl group at
δ (3H, s) and δ (H-3, m) peak. In addition,
29-oic acid), a pentacyclic triterpene skeleton, have been an
compound 4c and 7a displ