2010全国生物材料大会论文集之 (691).pdf

Stiffness Measurement of Burkitt’s Lymphoma Cells
with Atomic Force Microscopy
Mi Li*1,4, Lianqing Liu*1, Ning Xi1,2 ,Fellow, IEEE,
Yuechao Wang1, Zaili Dong1, Xiubin Xiao3 and Weijing Zhang*3

1 State Key Laboratory of Robotics, Shenyang Institute of Automation, CAS, Shenyang, 110016, China
2 Department of Electrical puter Engineering, Michigan State University, East Lansing, Michigan, 48824, USA
3 Department of Lyphoma, Affiliated Hospital of Military Medical Academy of Sciences, Beijing, 100071, China
4 Graduate School of Chinese Academy of Sciences, Beijing 100001, China

Abstract — Cell stiffness is closely related to human health and The first golden era of cancer drug development was
diseases. Measuring the mechanical property of individual cells initiated in the 1940s and gave rise to the cytotoxic agents that
may help us to understand the mechanism of diseases at cell level dominate current cancer medicine [10], and the second golden
and provide new methods for disease diagnosis and personalized era is directed by targeted molecular cancer therapeutics
treatment. In this paper, the poly-l-lysine was used to immobilize [11].Biomarker is a crucial part in drug development, which
Burkitt’s lymphoma (BL) cells onto the glass substrate for being
imaged in fluid by atomic force microscopy (AFM). In near- can reduce the attrition of drug