2010全国生物材料大会论文集之 (985).pdf

Acute toxicity of Milbemycin oxime in mice

Qianqian Xu, Jichang Li*, Mingli Qu, Yaoteng Zhang, Xiaolei Yu, Wensheng Xiang*
College of Veterinary Medicine
Northeast Agricultural University
Harbin, China
E-mail address: lijichang828@


Abstract—Milbemycin oxime, isolated from the fermentation hyperpolarisation of the neuromuscular membrane and
of Streptomyces hygroscopicus var. aureolacrimosus, is effective id paralysis and death of the parasite.
to parasites such as heartworm larvae, adult hookworm and Milbemycin oxime plete protection against
mites. Kunming mice were selected for the acute toxicity heartworm infection in both controlled laboratory and
study. The animals exposed to milbemycin oxime by single clinical trials. It brings about long term suppression of
intragastric administration. The pretest showed that gender microfilaremia without immediate adulticidal activity [4]. A
had effect on the LD50 value. Therefore, 70 male mice were dose of mg/kg of milbemycin pletely-
divided into 7 groups at random, each group was given protected the infection 15 to 60 days after infection, and
different concentration of milbemycin oxime, so did for the given monthly for 6 months at a dose of mg/kg can
female mice. Each animal was observed for signs of toxicity plete protection of Dirofilaria immitis infection
and behavioral change