2010全国生物材料大会论文集之 (988).pdf

Stochastic resonance algorithm for enhancement of
signal-to-noise ratio of HPLC/MS signal


23 Xizeng Road, Guangzhou 510160,P. R. China
Chang-Yun Chen
Department of Chemistry, Nanjing Xiaozhuang University
Nanjing 211171, P. R. China Hai-Shan Deng, Bing-Ren Xiang
y @ Center for Instrumental Analysis, China Pharmaceutical
University
Nanjing 210009, P. R. China
Shao-Fei Xie
Guangzhou Institute for Drug Control

noise ratio (SNR) in nonlinear dynamical system. The
phenomenon shows the counterintuitive role played by noise
Abstract—Based on the theory of stochastic resonance, a in nonlinear systems since it enhances the response of a
new method was presented to enhance signal-to-noise ratio system subject to a weak external signal[6]. There have been
(SNR) of HPLC/MS signal for trace analysis with a new several applications in improving analytical detection limits
optimization method of the system parameters. The method for trace analysis. Such as Pan et al. had improved the
was applied to experimental weak signals of HPLC/MS, which detectability of analytes in gas chromatography by utilizing
was embedded in the noise background and the SNR was the theory of SR[3]. Zhang et al. had essfully employed
enhanced greatly. The LOD and LOQ were improved from 10 SR to improve the detectability of liquid chromatography and
ng/ml and