宋晓霞 孙林 [摘要]目的 探討促性腺激素释放激素激动剂(GnRHa)在多囊卵巢综合征(PCOS)患者促排卵治疗中的应用效果。方法 选取2018年1~12月我院收治的100例PCOS患者作为研究对象,采用随机数字表法将其分为观察组(50例)和对照组(50例)。观察组患者采用GnRHa诱导排卵,对照组患者采用人绒毛膜促性腺激素(HCG)进行单纯促排卵治疗。比较两组患者的促排卵效果指标(卵泡成熟天数、成熟卵泡个数和排卵率),治疗前后雌孕激素[卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、孕***(P)]水平,以及治疗后卵巢过度刺激综合征(OHSS)发生率、自然妊娠率、多胎妊娠率、早期流产率和未妊娠患者的下次月经期卵巢囊肿发生率。结果 两组患者的卵泡成熟天数、成熟卵泡个数及排卵率比较,差异无统计学意义(P>);观察组患者治疗后FSH、LH水平与对照组比较,差异无统计学意义(P>);观察组患者治疗后的E2与P水平均低于对照组,差异有统计学意义();观察组患者治疗后的多胎妊娠率及OHSS发生率均低于对照组,差异有统计学意义(P [关键词]多囊卵巢综合征;促排卵;雌激素;妊娠率 [] [] A [] 1674-4721(2020)2(b)-0134-04 [Abstract] Objective To explore application effect of gonadotropin-releasing hormone agonist (GnRHa) in ovulation induction therapy of patients with polycystic ovary syndrome (PCOS). Methods A total of 100 PCOS patients treatedin the hospital from January to December in 2018 were enrolled in the study. They were divided into observation group and control group by random number table method, with 50 cases in each group. The observation group was given GnRHa to induce ovulation. The control group was given human chorionic gonadotropin (HCG) for simple ovulation induction therapy. The ovulation induction indexes (days for follicle maturity, number of mature follicles and ovulation rate), levels of estrogen and progestin such as follicle stimulating hormone (F