鹦鹉热衣原体基因工程疫苗研究进展
严专强 魏晓娜 周庆丰
摘 要:鹦鹉热衣原体(Chlamydia psittaci, Cps)是专性细胞内寄生、革兰氏阴性病原体,能在鸟类、人类和其它哺乳动物中广泛传播。Cps能够的生产和检验不需要使用衣原体活菌,确保了操作者的安全,是今后研发的主要方向。传统的亚单位疫苗需要解决外源性表达蛋白的稳定性、纯度以及蛋白降解等问题,而Cps表位疫苗、DNA疫苗和活载体疫苗等新型基因工程疫苗各具优势,具有广阔的应用前景。
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