类查尔酮氟喹诺酮衍生物的合成及抗肿瘤活性 冯亚莉.pdf

http / /www．hxtb．org 化学通报 2022 年 第 85 卷 第 4 期 ·485·
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Feng Yali Li Ke Huang Wenlong Cui Hongyan Hu Guoqiang
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Water Environment and Health Henan Engineering Technology Ｒesearch Center Zhengzhou University of
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Industrial Technology Zhengzhou 451150 School of Clinical Medicine Henan University Kaifeng 475001
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Centre of Drug Discovery China Pharmaceutical University Nanjing 210009
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Abstract Based on the structural features of α β-unsaturated ketones 12 novel chalcone-like fluoroquinolone
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target compounds 5a ～ 5l were designed and synthesized and th